NextGen Sciences and Expression Pathology to provide protein biomarker discovery and measurement in tissue

01-Jul-2008

NextGen Sciences, Inc (Ann Arbor, MI), a provider of biomarker services, and Expression Pathology, Inc. (Gaithersburg, MD), a leader in tissue protein analysis, announced that they have signed a commercial agreement to provide protein biomarker services in formalin-fixed paraffin-embedded (FFPE) tissue samples. The new combined offering will provide researchers with an improved, mass spectrometry based alternative to the commonly used immunohistochemistry method for identification and analysis of tissue proteins, reducing drug development timelines and providing accurate and quantitative measurement of protein biomarkers of disease progression, drug response and toxicity.

In addition to providing true quantitative protein analysis in FFPE tissue, which is not possible with current methods, the new services are expected to save months in the drug development process. Immunohistochemistry is laborious and often require several months for the production of an antibody against the protein of interest. However, the projects run by NextGen and Expression Pathology take less time to complete and do not require antibodies for protein quantitation.

To access the services, customers can send their FFPE tissue samples to either NextGen or Expression Pathology. Expression Pathology has developed innovative, proprietary techniques for microdissection, extraction and solubilization of the protein content of FFPE tissue. Customer samples are processed using the Company's Liquid Tissue® MS Protein Prep and Director(TM) laser micro-dissection technologies. Once extracted, the proteins are analyzed with NextGen's LC-MS/MS technologies to identify and quantify protein levels from healthy versus diseased or treated versus untreated samples. This workflow can be used at any stage of a project including biomarker discovery, biomarker assay development and biomarker testing. For discovery, the deliverable is a list of candidate protein biomarkers identified and quantified in each tissue sample. For biomarker testing, the deliverable is relative and/or absolute quantitation for the client's targeted list of protein biomarkers. See notes to editor for more technical details

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