NIS and Proteos launch TrueCourse Biosciences
New CRO for AI-driven drug discovery
NanoImaging Services, a cryo-EM CRO, and Proteos, a protein production research partner, have announced the launch of TrueCourse Biosciences, an integrated CRO that brings together advanced capabilities to help pharmaceutical and biotechnology companies navigate increasingly complex drug discovery programs.
Lindsey Gottler, PhD: Chief Executive Officer, TrueCourse Biosciences
TrueCourse Biosciences
Structural biology approaches like cryo-EM and X-ray crystallography combined with biophysical assays can help researchers developing AI drug discovery tools to validate their models.
TrueCourse’s expanded offering will address the changing needs of drug discovery teams. Customers can access multiple scientific services through a single partner, including:
- Protein production - producing high-quality proteins, including challenging targets such as membrane proteins, for structural biology, biophysics, assay development, and toxicology studies.
- Biolayer interferometry (BLI) and surface plasmon resonance (SPR) - assessing binding interactions and characterizing the relationships between drug candidates and their targets.
- Single particle analysis via Cryo-electron microscopy (cryo-EM) - determining the structures of complex biological targets and drug-target interactions, particularly where larger or more challenging targets are involved.
- X-ray crystallography - providing structure determination and enabling TrueCourse to support targets that may be better suited to X-ray analysis than cryo-EM.
- Nanoparticle characterization via cryo-transmission electron microscopy (cryo-TEM) - assessing the size, morphology, and structural integrity of nanoparticle formulations, including lipid nanoparticles (LNPs) and viral vectors.
To lead TrueCourse through its launch and growth strategy, Dr. Lindsey Gottler has been appointed Chief Executive Officer. Dr. Gottler brings a deep knowledge of protein science and CRO leadership, having progressed through multiple scientific and leadership positions, including Director of the Protein Purification Group and Chief Scientific Officer at Proteos.
Dr. Gottler said of the news: “Bringing NanoImaging Services and Proteos together under TrueCourse allows us to offer a more connected approach to structural biology, while building on the deep scientific expertise that has defined both organizations. By expanding our capabilities and connecting them more closely, we can help researchers cut through complexity, reduce uncertainty and identify the clearest path forward for their programs.”
With operations across California, Massachusetts and Michigan, TrueCourse will support a diverse customer base spanning large pharmaceutical companies, biotechnology companies and emerging drug discovery organizations.
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