Agilent Technologies introduces industry's first HPLC-chip/MS system for proteomics

25-Feb-2005

Agilent Technologies Inc. introduced the first high-performance liquid chromatography (HPLC)- chip/mass spectrometry (MS) system for protein identification. This breakthrough microfluidics-based LC/MS technology is expected to significantly increase the speed, ease and productivity of proteomics research.

Many biomedical researchers employ proteomics, the systematic analysis of protein expression, structure and function, to study the underlying causes of diseases such as cancer. Traditional techniques used to prepare protein samples for MS analysis, such as nanoflow LC, require complex arrangements of equipment in order to improve separation power, and consume relatively large quantities of sample. Agilent's innovative new system simplifies LC/MS, heightens separation power and sensitivity, and reduces required sample sizes by integrating multiple functionalities on a single microfluidics-based chip.

Agilent's Protein ID HPLC-Chip (G4240A) offers greater peptide coverage and higher protein identification compared with nanoflow LC/MS. Smaller than a credit card, the company's unique HPLC-Chip for protein identification seamlessly integrates sample enrichment and separation capability of a nanoflow LC system with the intricate connections and spray tips used in electrospray mass spectrometry. The technology eliminates 50 percent of the fittings and connections typically required in an LC/MS system, dramatically reducing the possibility of leaks and dead volumes, significantly simplifying workflow, and increasing sensitivity and reliability during analysis.

To enable compliance and experiment management, the HPLC-Chip includes a radio frequency tag that contains information such as chip ID and type, documentation, diagnostic and operational data, and additional memory for user comments.

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