Scientists from Trinity College Dublin and AMBER, the SFI Research Centre for Advanced Materials and BioEngineering Research, have discovered a way to fabricate tiny colour-changing gas sensors using new materials and a high-resolution form of 3D printing. The sensors – responsive, printed, ... more
Major breakthrough identifies new mechanism for the development of schizophrenia
Scientists from Trinity College Dublin and the Royal College of Surgeons in Ireland (RCSI) have discovered that abnormalities of blood vessels in the brain may play a major role in the development of schizophrenia, a debilitating condition that affects around 1% of people in Ireland.
The network of blood vessels in the brain regulates the transport of energy and materials in and out of the brain -- forming what is known as the blood-brain barrier (BBB). Scientists working in the Smurfit Institute of Genetics at Trinity College Dublin and the Department of Psychiatry, RCSI, have discovered that abnormalities in the integrity of the BBB may be a critical component in the development of schizophrenia and other brain disorders.
The research was supported by the Health Research Board (HRB), Science Foundation Ireland (SFI) and the US-based charity, Brightfocus Foundation.
People living with a chromosomal abnormality termed '22q11 deletion syndrome' (22q11DS) are 20 times more likely to develop schizophrenia. These people lack approximately 40-60 genes within a small region in one of the pairs of chromosome 22. A gene termed "Claudin-5" is located within this region, and it is changes in the levels of this component of the BBB that are associated with the presence of schizophrenia.
Assistant Professor in Neurovascular Genetics at Trinity, Dr Matthew Campbell, said: "Our recent findings have, for the first time, suggested that schizophrenia is a brain disorder associated with abnormalities of brain blood vessels. The concept of tailoring drugs to regulate and treat abnormal brain blood vessels is a novel treatment strategy and offers great potential to complement existing treatments of this debilitating disease."
"While it is very well accepted that improving cardiovascular health can reduce the risk of stroke and heart attacks, we now believe that drugs aimed at improving cerebrovascular health may be an additional strategy to treating brain diseases in the future."
Working with an international group of scientists from Cardiff University, Stanford University and Duke University in addition to screening post-mortem brain samples from the Stanley Medical Research Institute, the scientists are the first to identify a molecular genetic component of the blood brain barrier with the development of schizophrenia.
Professor Kieran Murphy, Head of Department of Psychiatry, RCSI and Consultant Psychiatrist at Beaumont Hospital, said: "We have shown for the first time that dysfunction of the blood-brain barrier may be an important factor in the development of schizophrenia. These findings greatly add to our understanding of this debilitating and socially isolating condition."
- Trinity College Dublin
- blood vessels
- blood-brain barrier
- chromosomal abnormalities
- genetic diseases
From nearly 60 submissions for the 2017 WITec Paper Award, our jury selected the three best publications. They were written by scientists from Ireland, Portugal and Germany who used WITec correlative confocal Raman microscopes to study transition metal dichalcogenides, textile fibers and ce ... more
If you've ever wondered why some allergic reactions progress quickly and may even become fatal, a new research report published in the Journal of Leukocyte Biology provides an important part of the answer. In the report, scientists from Queen's University of Belfast, University of Oxford an ... more
- 1COVID-19 : Measuring viral RNA to predict which patients will die
- 2Why are neuron axons long and spindly?
- 3Rapid PCR tests at the touch of a button
- 4Mini-laboratory delivers results in about 40 minutes at the point of care
- 5Binary mesocrystals from the nanobuilding kit
- 6SCHOTT Is Now a Stock Corporation
- 7Blood biomarker identified that predicts type 2 diabetes many years before diagnosis
- 8Method to reveal undesired biological effects of chemicals
- 9Wastewater provides new insight into Covid-19 dynamics
- 10Pioneering new technique to barcode cells
- Scientists create 3D-printed, microscopic gas sensors - painters’ pallets without even a hint of pigment
- Major breakthrough identifies new mechanism for the development of schizophrenia
- Detecting Mercury with Gold
- SYGNIS signs non-exclusive distribution agreement with Cambridge Bioscience Ltd. for UK and Ireland
- JPK announces the appointment of new UK & Ireland Sales Manager