Gene editing has been a much sought after and controversial technology. Last month, part of the World Health Organization called for an international registry to track all research into editing the human genome. Purdue University researchers, including one who was inspired by the cancer dea ... more
Cancer identity technology makes it easier to find a tumor's 'address'
Purdue University researchers have developed a technology aimed at making it easier to deliver cancer treatment to the right "address" in the body while also easing the painful side effects of chemotherapy on patients.
One of the big issues with chemotherapy is that most treatment approaches focus on the tumor itself without paying significant attention to the microenvironment surrounding the tumor.
"The traditional approach is similar to a delivery driver trying to drop off a package to a certain person without knowing their specific address," said Yoon Yeo, a professor of industrial and physical pharmacy at Purdue, who is leading the research team. "Our new approach provides directions to find the specific address to deliver the chemotherapeutic drugs."
The Centers for Disease Control and Prevention reports that each year, about 650,000 cancer patients receive chemotherapy in an outpatient oncology clinic in the United States. Patients receiving chemotherapy are at risk for various side effects that may lead to hospitalization, disruptions in chemotherapy schedules, and even death.
The Purdue method uses nanoparticles, which are considered promising carriers of drugs needed for chemotherapy to target tumors. The researchers developed a technique to prepare polyol-modified nanoparticles so they locate cancerous cells and tumors by checking out blood vessels surrounding the tumors.
The nanoparticles then interact with the vascular lining to enter tumors and destroy them. The Purdue researchers said their method helps the nanoparticles to exit from the circulation and enter tumors and better treat the cancer. They have tested the method on breast cancer and melanoma models and believe it also will prove effective for many types of cancerous tumors.
"Chemotherapy can be almost unbearable for most patients and we want to change that," Yeo said. "Our method better targets tumors so lower dosages are required and the drugs do less damage to normal tissues."
- side effects
- chemotherapeutic drugs
- blood vessels
- drug delivery
Purdue University researchers have developed a new flexible and translucent base for silicon nanoneedle patches to deliver exact doses of biomolecules directly into cells and expand observational opportunities."This means that eight or nine silicon nanoneedles can be injected into a single ... more
Waters Corporation, Prosolia, Inc. and the Purdue Research Foundation announced that Waters® acquired exclusive rights to Desorption Electrospray Ionization (DESI) technology for all mass spectrometry applications from Prosolia and PRF. "The acquisition of DESI technology bolsters Waters' p ... more
A new automated system detects cracks in the steel components of nuclear power plants and has been shown to be more accurate than other automated systems. more
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