Infrared light to detect early signs of esophageal cancer
Scientists have developed an endoscope that uses near-infrared light to spot early warning signs of oesophageal - food pipe - cancer, according to research.
Researchers at the Cancer Research UK Cambridge Institute sprayed a dye on oesophageal tissue samples taken from people with Barrett's oesophagus - a condition that increases the risk of developing oesophageal cancer. The dye sticks to healthy oesophageal cells but not to pre-cancerous cells.
They then shone near-infrared light on the tissue, which is just beyond the red colours that our eyes can normally see, and used a special camera to detect the near-infrared light the dye gave out.
Researchers had tried this approach before but had used a dye that gave out visible light to spot pre-cancerous cells. Problems arose because when cells are exposed to visible light, they naturally emit visible light themselves - making the distinction between healthy and abnormal cells hard to see.
But, by using a dye that gives out near-infrared light, scientists refined the process so they could make the distinction.
This new technique could be used to monitor people with Barrett's oesophagus who have an increased risk of developing oesophageal cancer, and spot early signs that cancer might be developing before the person has any symptoms.
Dr Sarah Bohndiek, scientist at the Cancer Research UK Cambridge Institute, said: "This research gives us hope for developing better techniques to detect the disease early.
"People who are at a high risk of developing oesophageal cancer, such as those with Barrett's oesophagus, could be closely monitored with this technique. And removing patches of pre-cancerous cells could prevent some cases of oesophageal cancer. But we need to do some further testing before clinical trials with patients can be set up to see how effective the approach could be at saving lives."
There are around 7,800 deaths from oesophageal cancer every year in the UK. For men, oesophageal cancer is the fourth most common cause of cancer death.
Dr Emma Smith, science communication manager at Cancer Research UK, said: "Early detection is crucial if we want to cure more cancers and save more lives. And oesophageal cancer is often caught at an advanced stage, meaning survival rates of the disease have remained stubbornly low.
"We urgently need new ways to detect the disease early. This development could lead to a cheaper, better way of detecting the warning signs of oesophageal cancer and even stop some people developing the disease."
Original publication
Other news from the department science
Most read news
More news from our other portals
Last viewed contents
Brooks Instrument Joins Major Biotechnology Consortium Focused on Regenerative Drug Manufacturing - Brooks Instrument will contribute insights and precision fluid control technology to the Advanced Regenerative Manufacturing Institute’s BioFabUSA program
Promising discovery for a non-invasive early detection of Alzheimer's disease
Innovations through hair-thin optical fibres - Study shows what miniaturised optical filters make possible
Wave of the future - Terahertz chips a new way of seeing through matter
Using PETRA III to watch the disabling of a penicillin killer - Scientists observe in detail the binding and formation of covalent bonds of an inhibitor to a bacterial enzyme that disables common antibiotics
Eurofins acquires LGC Forensics
How pathogenic bacteria prepare a sticky adhesion protein
How the brain might compensate stress during learning
The Combined Nanoscopy Technique - Scientists develop a combined technique for studying cellular structures via high-resolution imaging
Thermo Fisher Scientific Strengthens Life Sciences Portfolio With the Addition of Spectronex and Flux Instruments
