Researchers have developed a technology to analyze the adsorption behavior of molecules in each individual pore of a metal organic framework (MOF). This system has large specific surface areas, allowing for the real-time observation of the adsorption process of an MOF, a new material effect ... more
Gallium-based solvating agent efficiently analyzes optically active alcohols
A KAIST research team has developed a gallium-based metal complex enabling the rapid chiral analysis of alcohols. A team working under Professor Hyunwoo Kim reported the efficient new alcohol analysis method using nuclear magnetic resonance (NMR) spectroscopy in iScience.
Enantiopure chiral alcohols are ubiquitous in nature and widely utilized as pharmaceuticals. This importance of chirality in synthetic and medicinal chemistry has advanced the search for rapid and facile methods to determine the enantiomeric purities of compounds. To date, chiral analysis has been performed using high-performance liquid chromatography (HPLC) with chiral columns.
Along with the HPLC technique, chiral analysis using NMR spectroscopy has gained tremendous attention as an alternative to traditionally employed chromatographic methods due to its simplicity and rapid detection for real-time measurement. However, this method carries drawbacks such as line-broadening, narrow substrate scope, and poor resolution. Thus, compared with popular methods of chromatographic analysis, NMR spectroscopy is infrequently used for chiral analysis.
In principle, a chiral solvating agent is additionally required for the NMR measurement of chiral alcohols to obtain two distinct signals. However, NMR analysis of chiral alcohols has been challenging due to weak binding interactions with chiral solvating agents. To overcome the intrinsic difficulty of relatively weak molecular interactions that are common for alcohols, many researchers have used multifunctional alcohols to enhance interactions with solvating agents.
Instead, the KAIST team successfully varied the physical properties of metal complexes to induce stronger interactions with alcohols rather than the strategy of using multifunctional analytes, in the hopes of developing a universal chiral solvating agent for alcohols. Compared to the current method of chiral analysis used in the pharmaceutical industry, alcohols that do not possess chromophores can also be directly analyzed with the gallium complexes.
Professor Kim said that this method could be a complementary chiral analysis technique at the industry level in the near future. He added that since the developed gallium complex can determine enantiomeric excess within minutes, it can be further utilized to monitor asymmetric synthesis. This feature will benefit a large number of researchers in the organic chemistry community, as well as the pharmaceutical industry.
- chiral analysis
- NMR spectroscopy
- chiral alcohols
Nanogenerators are self-powered energy harvesters that convert kinetic energy created from vibrational and mechanical sources into electrical power, removing the need of external circuits or batteries for electronic devices. This innovation is vital in realizing sustainable energy generatio ... more
Many chemicals we use in everyday life are derived from fossil resources. Due to the increasing concerns on the use of fossil resources, there has been much interest in producing chemicals from renewable resources through biotechnology. Phenol is an important commodity chemical, and is a st ... more
- 1analytica 2020: World’s leading trade fair to be held virtually
- 2analytica 2020: The world’s leading trade fair extends its reach with analytica virtual
- 3Portable, point-of-care COVID-19 test could bypass the lab
- 4Researchers dramatically downsize technology for fingerprinting drugs and other chemicals
- 5Attacking tumours directly on identification
- 6Towards a cell-based interceptive medicine in Europe
- 7Giant nanomachine aids the immune system
- 8A tiny instrument to measure the faintest magnetic fields
- 9Leap forward in the fight against antibiotic resistance
- 10New device can measure toxic lead within minutes
- Right under your nose: A more convenient way to diagnose Alzheimer's disease
- Gallium-based solvating agent efficiently analyzes optically active alcohols
- Development of simplified new mass spectrometric technique using laser and graphene
- World's smallest MRI performed on single atoms
- Real-time analysis of MOF adsorption behavior