The tiny size of conventional diatomic molecules in the sub-nanometer regime hinders direct optical resolution of their constituents. Physicists from the Quantum Many Body Division at MPQ led by Prof. Immanuel Bloch were able to bind pairs of highly excited atoms at a distance of one microm ... more
Biomarkers indicate health in old ageResearchers can determine the disease vulnerability of older people using a defined set of substances in the blood
Researchers on ageing found a combination of biomarkers in the blood which could help estimate the disease vulnerability of elderly people.
Researchers on ageing from the Max Planck Institute for Biology of Ageing and the Leiden University Medical Center (LUMC) collaborate to link basic insights from model organisms to the causes of ageing in humans. They found a combination of biomarkers in the blood which could help estimate the disease vulnerability of elderly people in clinical studies and could possibly be used in intervention studies in model organisms that slow down ageing.
When basic researchers investigate the molecular basis of ageing, they usually study model organisms such as worms, fruit flies or mice. The Max Planck Institute for Biology of Ageing aims to link basic insights into ageing to the causes and processes underlying ageing-associated diseases in humans and has therefore recruited Prof. Eline Slagboom from the Leiden University Medical Center in the Netherlands (LUMC) as a Max Planck Fellow in 2018. Now the researchers have identified a set of biomarkers in human blood which could be used in parallel in clinical studies and in ageing research on model organisms.
The scientists searched in blood samples of 44,168 individuals for biomarkers that are indicative of a person’s remaining lifespan. After an extensive analysis, the scientists arrived at a set of 14 biomarkers which include for example, various amino acids – the building blocks of proteins – and levels of ‘good’ and ‘bad’ cholesterol, fatty acid balances and inflammation.
The blood-based measurement is intended as a first step towards a more personalised treatment of the elderly, explains study director Prof. Eline Slagboom. “As researchers on ageing, we are keen to determine the biological age. The calendar age just doesn’t say very much about the general state of health of elderly people: one 70-year-old is healthy, while another may already be suffering from three diseases. We now have a set of biomarkers which may help to identify vulnerable elderly people, who could subsequently be treated.”
The set of biomarkers is also a starting point for parallel studies in model organisms. “Ageing research in model organisms is ahead of that in humans. To make use of that knowledge we need instruments to compare human and animal studies and this could be one. We are currently investigating if the identified substances can be found in the blood of typical model organisms such as mice and if they are affected by interventions in ageing.”, explains Slagboom. The researchers are now working on answering these questions together with the Cluster of Excellence for Aging Research at the University of Cologne.
This large-scale study was possible through collaboration of LUMC with international biobanks, BBMRI-NL (Biobanking and BioMolecular resources Research Infrastructure the Netherlands) and the Max Planck Institute for Biology of Ageing in Cologne.
Joris Deelen, (...), Eline P. Slagboom; "A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals"; Nature Communications; 20. August 2019
- blood analysis
A risk score based on many genetic differences predicts which children and adolescents are at greater risk of depression. An international team led by Munich-based researchers have found a genetic score that reliably predicts in youths who will have depression, the severity of the depressio ... more
Two astronomers from the Max Planck Institute for Astronomy and from the University of Jena have found an elegant new method to measure the energy of simple chemical reactions, under similar conditions as those encountered by atoms and molecules in the early solar system. Their method promi ... more
- 1Eye scan makes diseases visible at an early stage
- 2Biomarkers indicate health in old age
- 3PerkinElmer Announces Leadership Succession Plan
- 4First high-speed hard X-ray microscopic movies at a free-electron laser
- 5Tomoscopy: new imaging method
- 6David Alsteens Receives 2019 Heinrich Emanuel Merck Award for Analytical Science
- 7Retina-on-a-chip provides powerful tool for studying eye disease
- 8Google Maps for tissues
- 9How do atoms vibrate in graphene nanostructures?
- 10An innovative new diagnostic for Lyme disease