The Republic of Korea, like other countries with a rapidly ageing population, is facing increasing numbers of patients with dementia, of which Alzheimer's disease (AD) is the most representative type. Unfortunately, AD has no complete cure yet; but, some treatments have been proven to delay ... more
Development of simplified new mass spectrometric technique using laser and graphene
A technology that can obtain high-resolution, micrometer-sized images for mass spectrometric analysis without sample preparation has been developed. DGIST Research Fellow Jae Young Kim and Chair-professor Dae Won Moon's team succeeded in developing the precise analysis and micrometer-sized imaging of bio samples using a small and inexpensive laser.
DGIST announced that Research Fellow Jae Young Kim in the Department of Robotics Engineering and Chair-professor Dae Won Moon's team developed a technology that can analyze experiment samples without any preparation processing. Due to its ability to obtain high-resolution mass spectrometric images without an experimental environment using 'continuous wave laser', the technology is expected to be applied widely in the precise medicine and medical diagnosis fields.
Many advance preparations are needed for the mass spectrometric imaging of biometric samples using 'specimen,' which thinly cut an object to analyze. The specimen must be changed artificially since they cannot be analyzed accurately in a room temperature or atmospheric pressure. To develop a convenient analysis technology and ease the burden, Research Fellow Kim started the research.
The research team installed a lens carrying continuous wave laser right below a microscope substrate where the specimen is put and shot the laser on it to measure mass spectra by examining molecules from desorption.
The mass spectra can be analyzed through a continuous wave laser whose energy is weaker than other lasers because of the use of 'graphene substrate' below the specimen.
Since the honeycomb-patterned graphene has very high heat conductivity and can convert light into heat, it can secure enough heat needed for specimen analysis with small amount of light generated by the continuous wave laser. This technology is also advantageous for obtaining high-resolution analysis images, because it can secure space to observe specimen much more closely even when using a 20x magnifying lens.
Chair-professor Dae Won Moon in the Department of New Biology explained that "Through this technology, we could greatly shorten the preparation time for analysis by omitting the specimen preprocessing step. Our next plan is to develop the technology further so it can be applied in various areas such as medical diagnosis."
- mass spectrometry
- medical diagnostics
A research team led by DGIST Professor Moon Cheil at the Department of Brain and Cognitive Sciences has identified the reason why the patients with the early stage of Alzheimer's fail to smell. The research team of Professor Moon Cheil conducted a joint research with the research teams led ... more
- 1Detect neurodegenerative diseases such as Alzheimer's by a simple eye scan?
- 2Fluorescence microscopy at highest spatial and temporal resolution
- 3The Mechanics of the Immune System
- 4Resolve Biosciences Launches New Era in Single-Cell Spatial Analysis
- 5Quick look under the skin
- 6New ion trap to create the world's most accurate mass spectrometer
- 7How does your computer smell?
- 8Clocking electron movements inside an atom
- 9Sartorius closes 2020 with strong growth
- 10A clear path to better insights into biomolecules
- The indestructible light beam
- Researchers develop blood test for depression, bipolar disorder
- Aviation safety: Rapid test for harmful microbes in kerosene developed
- Doping by athletes could become tougher to hide with new detection method
- First images of cells exposed to COVID-19 vaccine reveal native-like Coronav ...
- Hunting out hidden hydrogen: novel holey nanosheets for detecting hydrogen gas leaks
- Waters Collaborates with Dr. Sunghwan Kim of Kyungpook National University to Advance Precision Analysis of Complex Chemical Compounds
- Right under your nose: A more convenient way to diagnose Alzheimer's disease
- Gallium-based solvating agent efficiently analyzes optically active alcohols
- Development of simplified new mass spectrometric technique using laser and graphene