Waters and Sartorius Expand Collaboration to Deliver Comprehensive Bioanalytics for Downstream Biomanufacturing

06-Jun-2023 - Waters Corporation and Sartorius announced a new collaboration to develop integrated analytical solutions for downstream biomanufacturing, expanding their joint agreement that began with upstream bioprocessing analytics. Software and hardware integrations between the Waters™ PATROL™ ...

Novel AI-based software enables quick and reliable imaging of proteins in cells

Researchers programmed a tool that accurately recognises and picks proteins in electron cryo-tomography, substituting troublesome hand selection

24-May-2023 - Electron cryo-tomography (cryo-ET) is emerging as a powerful technique to provide detailed 3D images of cellular environments and enclosed biomolecules. However, one of the challenges of the methodology is the identification of protein molecules in the images for further processing. A research ...

Time-resolved crystallography for the masses

“The Spitrobot will greatly accelerate research in enzymatic mechanisms"

08-May-2023 - Scientists from four research institutes in the Science City Hamburg Bahrenfeld have joined forces to develop a ground-breaking experimental setup. Their new Spitrobot greatly simplifies observing changes in proteins as they carry out their functions. This makes time-resolved crystallography ...

How artificial intelligence can improve protein detection

Using AI to move the boundaries of microscopy

12-Apr-2023 - Small proteins play a critical role in the regulation of immune response, inflammation and neurodegenerative diseases. In order to better detect and study them, scientists at the Max-Planck-Institute for the Science of Light and FAU have combined one of the most effective microscopy methods, ...

A further advance in super-resolution fluorescence microscopy

Fast even at the nanometer level

14-Mar-2023 - Scientists led by Nobel Laureate Stefan Hell at the Max Planck Institute for Medical Research in Heidelberg have developed a super-resolution microscope with a spatio-temporal precision of one nanometer per millisecond. An improved version of their recently introduced MINFLUX super-resolution ...

Enhancing at-home COVID tests with glow-in-the dark materials

09-Mar-2023 - Researchers at the University of Houston are using glow-in-the-dark materials to enhance and improve rapid COVID-19 home tests. If you’ve taken an at-home COVID-19 or pregnancy test, then you’ve taken what is scientifically called a lateral flow assay (LFA) test, a diagnostic tool widely used ...

How biomolecules react to UV light

Innovative experiment reveals ultrafast dynamics of proteins in their environment

02-Jan-2023 - A sophisticated experiment provides new insights into the ultrafast reaction of biomolecules when they are hit by energetic ultraviolet light in their natural environment. The team of DESY scientist Jochen Küpper recorded the light-induced processes taking place in a small complex of two ...

Shedding New Light on Viruses

Analysis of viruses with a combination of mass spectrometry and X-ray laser

19-Dec-2022 - Professor Dr. Charlotte Uetrecht from the University of Siegen is studying the structures of proteins and protein complexes in coronaviruses and noroviruses, and how they change over the viral lifecycle. She is developing a new method to obtain as much information as possible about states of ...

Imaging the dynamic cellular zoo made easier

This work will expand the ability to simultaneously monitor many processes in cells

22-Nov-2022 - Imagine the difficulty of visually keeping track of five people scattered throughout a stadium. Researchers perform far more amazing feats by simultaneously tracking many different cellular factors, but they need an expanded fluorescence toolkit to advance current capabilities. Now, in a study ...

Medicines with Sugar Chains

Native top-down mass spectrometry reveals role of glycans in protein oligomers

17-Nov-2022 - Many proteins contain patterns of sugar molecules (glycans) and are made of several aggregated subunits. This glycosylation and oligomerization has a decisive influence on protein function and must be considered in biopharmaceutical development. In the journal Angewandte Chemie, a British team ...