If radiation or chemotherapy treatment of leukaemias or lymphomas does not bring sufficient success, the transplantation of bone marrow or blood stem cells is usually the only chance of cure. Unfortunately, the majority of patients die despite transplantation, often due to spontaneous infec ... more
Multi-organ platform for risk assessment of nanomaterials
Multimodular microchip platform for predicting the behaviour of nanomaterials in the body
Nanomaterials are already part of everyday life in our modern society. New applications, along with continuously rising quantities being produced, have led to an increased exposure to nanomaterials for both people and the environment. Predicting the behaviour of nanomaterials in organisms and extensive risk assessments are currently difficult because we are missing prediction models.
How do these small particles with a size of only few millions of a millimetre overcome the protective layers of our body? How do the particles behave in the organism? Are the particles metabolised and are they dangerous? In order to find answers to these and other questions, 11 partners from business and science are developing new, innovative methods for precise detection of the behaviour of nanomaterials in the body and for better prediction and safe evaluation of the resulting risks for humans. This work is being done within the framework of the EU-project »HISENTS: High level integrated Sensor for Nanotoxicity Screening«.
Due to their small size and varied physical and chemical properties, nanoparticles can perform special functions and are today incorporated in a large number of everyday products. Nanoparticles are present in cosmetics, textiles, cleaning agents, sprays, packages as well as in food and dietary supplements and thus enter the human body day-to-day. Even the application of nanoscale particles in the pharma or medical sector is no longer a rarity. Therapeutics (e. g. drugs for chemo- or phototherapy) and diagnostics (e. g. contrast agents) as well as coatings of implants are increasingly based on nanomaterials.
Due to the numerous knowledge gaps and lack of model systems, so far only insufficient prediction of absorption, distribution, metabolism and excretion (ADME) of synthetic nanomaterials in the human organism is possible. In the pharmaceutical research and drug development industry the PBPK model (physiologically based pharmacokinetic model) is chosen as an established approach for the mathematical prediction of kinetic profiles of medical compounds regarding dose, route and species. In doing so the concentration in the tissues and toxic, as well as pharmacologic, effects are included. »Up to now only initial approaches of such models exist for nanomaterials«, explains Dr. Yvonne Kohl, Group Manager Nanotoxicology at the Fraunhofer Institute for Biomedical Engineering IBMT.
- risk assessment
- nanoparticle concentration
- chemical screening
Cell-based biosensors can simulate the effect of various substances, such as drugs, on the human body in the laboratory. Depending on the measuring principle, though, producing them can be expensive. As a result, they are often not used. Cost factors for sensors that perform measurements el ... more
A wide range of industrially synthesized nanomaterials are present in products we use daily and, in the meantime, are part of our everyday life. Due to their exceptional properties (e. g., increased UV-filtration or stronger adhesion) they are used in clothes, cosmetics, household goods and ... more
Microscopy is at the forefront of the fight against the coronavirus. Special microscopes, which enable scientists to view minute cell structures, are an indispensable tool in the development of vaccines and new therapies. Such equipment comprises not only a microscope with high optical reso ... more
The air we exhale contains information that can assist with the diagnosis of disease. Researchers at the Fraunhofer Project Hub for Microelectronic and Optical Systems for Biomedicine MEOS are now developing solutions designed to enable the analysis of breath gas for this purpose. Although ... more
The need for everyday objects with antiviral surfaces is high due to the COVID 19 pandemic. It is known that the material composition of an object has an influence on the viability of viruses on surfaces. This is where the work of the Fraunhofer IFAM comes in: In cross-disciplinary research ... more
One-stop-shop for the development of system control boards for IVD applications using modular electronics ✓ System integration & interoperability testing: Libraries for medical data communication-POCT1-A, POCT1-A2 ✓ Digital Pathology and Medical Image Processing for Microscopy and Endoscopy ... more
We communicate at eye level for customer oriented development ✓ We cover the process from idea generation over feasibility studies to prototyping ✓ Tailor-made detection systems for a wide range of analytes - biomarkers, germs, toxins and more ✓ more
Digitalization and artificial intelligence are changing diagnostics in clinical routine and pharmaceutical research. New IVD devices are coming out, laboratory data is connected to the hospital IT system and AI-based image analysis enables new and efficient processes in digital pathology an ... more
At Fraunhofer IZI-BB we develop analytical and biotechnological solutions for medical issues, animal health, food, cosmetics and the environment. Our research focuses on sample preparation, development of molecular recognition elements and data acquisition as well as miniaturization and aut ... more
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