Immune cells that process food and bacterial antigens in the intestines control the intestinal population of fungi, according to a new study from Weill Cornell Medicine scientists. Defects in the fungus-fighting abilities of these cells may contribute to some cases of Crohn's disease and ot ... more
For salmonella detection, genomic tool emerges as a key
The world's food supply will become safer as the food industry shifts to high-resolution, whole-genome sequencing - which examines the full DNA of a given organism all at once. This move to make sequencing ubiquitous will lead to the consistently reliable detection of salmonella.
A paper published in the journal Frontiers in Microbiology on - co-authored by researchers from Cornell University and the Mars Global Food Safety Center (GFSC), Beijing - illuminates breakthroughs.
"Salmonella is the foodborne pathogen with the biggest public health and economic impact globally. It's one of the major causes of diarrhea all around the world," said Martin Wiedmann, food safety professor and Cornell Institute for Food Systems faculty fellow. "Salmonella can be mild or it can cause death, as its severity depends on salmonella's serotypes [distinct variations] - and that's what we're trying to find out."
The paper describes how the food industry around the world should use molecular methods more often for subtyping and characterizing salmonella. The paper compared older subtyping practices - some practices going back to the 1930s - to the newer whole-genome sequencing, a method that can analyze a wider, more complete swath of the genome.
With this technique, scientists can more precisely identify a particular strain of salmonella and determine the origin and the path of the disease's outbreak, Wiedmann said.
For example, in early July the U.S. Food and Drug Administration and the federal Centers for Disease Control and Prevention (CDC) used the technique, as they began investigating a suspected salmonella link between pig-ear dog treats and humans - due to people handling the treats. At the time, there were 45 cases of salmonella in 13 states, with 12 people hospitalized, according to the CDC.
"Whole-genome sequencing is rapidly becoming the method of choice for salmonella subtyping," said microbiologist Silin Tang, the paper's lead author and senior research scientist at the Mars Global Food Safety Center. "Foods often reach the consumer through increasingly complex supply chains, creating many opportunities where food safety could be compromised. Recent cases highlight the need to reinforce salmonella control measures in the food industry, including rapid and accurate tracking of contamination sources with appropriate subtyping tools."
Tang said there is an opportunity for the food industry to create a talent pipeline of expertise in bioinformatics - the use of software tools to understand biological data - to harness the full potential of whole-genome sequencing technologies.
Further, Wiedmann said, this paper represents the translation of academic analysis into a useful industry application. "This will help industry implement better ways to proactively address the complications and complexity of salmonella," he said.
- whole genome sequencing
- food industry
- Cornell University
Melanoma, a cancer of skin pigment cells called melanocytes, will strike an estimated 87,110 people in the U.S. in 2017, according to the Centers for Disease Control and Prevention. A fraction of those melanomas come from pre-existing moles, but the majority of them come from sources unknow ... more
With the introduction of CBETA, the Cornell-Brookhaven ERL Test Accelerator, Cornell University and Brookhaven National Laboratory scientists are following up on the concept of energy-recovering particle accelerators first introduced by physicist Maury Tigner at Cornell more than 50 years a ... more
- 1Eye scan makes diseases visible at an early stage
- 2Biomarkers indicate health in old age
- 3PerkinElmer Announces Leadership Succession Plan
- 4First high-speed hard X-ray microscopic movies at a free-electron laser
- 5Tomoscopy: new imaging method
- 6How do atoms vibrate in graphene nanostructures?
- 7Google Maps for tissues
- 8Retina-on-a-chip provides powerful tool for studying eye disease
- 9David Alsteens Receives 2019 Heinrich Emanuel Merck Award for Analytical Science
- 10FLAM-seq: the full picture of messenger RNA and their tails