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Unchartered territory in the human genome

18-Jul-2022

An international consortium brings together 7,200 segments of the human genome that are virtually unexplored and presents a roadmap for integrating them into genome databases in “Nature Biotechnology”. They could hold information about what sets humans apart from other animals. When researchers ...

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AI identifies cancer cells

“Ikarus lets us identify genes that are potential drivers of cancer”

14-Jun-2022

How do cancer cells differ from healthy cells? A new machine learning algorithm called “ikarus” knows the answer, reports a team led by MDC bioinformatician Altuna Akalin in the journal Genome Biology. The AI program has found a gene signature characteristic of tumors. When it comes to ...

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Study links eczema to rare gene variants

New therapies on the horizon

22-Dec-2021

In a genome-wide association study, an MDC research group led by Young-Ae Lee discovered several rare gene variants that increase susceptibility to eczema. The team has now published its findings in Nature Communications. Up to 20 percent of children and three percent of adults worldwide suffer ...

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Tracking RNA through space and time

Completely new avenues for studying such things as the mechanism of action of drug therapies

10-Jun-2021

A research team at the MDC has succeeded in tracking genes through space and time within a one-cell zebrafish embryo – even before cell division occurs. They have now described a method in the journal “Nature Communications” that may one day allow scientists to measure cell response to drugs, for ...

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Getting to the heart of an enzyme

Decoding the heart of NatC: X-rays help shed light on structure

10-Nov-2020

A team led by Oliver Daumke at the MDC has determined the three-dimensional structure of the NatC acetyltransferase in an article published in Nature Communications. This enzyme modifies cell proteins to enable them to perform their functions correctly. In cancer cells, however, NatC is often ...

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Towards a cell-based interceptive medicine in Europe

Diagnose diseases earlier and intercept disorders before irreparable damage occurs

09-Sep-2020

Hundreds of researchers, clinicians, industry leaders and policy makers from all around Europe are united by a vision of how to revolutionize healthcare. In a perspective in Nature and the LifeTime Strategic Research Agenda they now present a roadmap of how to leverage the latest scientific ...

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Diagnostics, meet CRISPR

15-Apr-2020

A new diagnostic test to quickly and easily monitor kidney transplant patients for infection and rejection relies on a simple urine sample and a powerful partner: the gene-editing technology CRISPR. Michael Kaminski, who developed it, leads a new Emmy Noether Group at the MDC & Charité. The ...

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On the trail of cancer stem cells

What goes on inside and between individual cells during the very earliest stages of tumor development?

24-Feb-2020

Single cell sequencing technologies and a mouse model have enabled researchers to comprehensively map the cellular diversity of whole salivary gland tumors and trace the path of cancer stem cells. Two research teams from the Max Delbrück Center for Molecular Medicine and their collaborators have ...

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Tracking titin in real time

17-Dec-2019

Using new high-resolution imaging techniques, MDC researchers and colleagues have tracked titin, the body’s largest protein, in real time throughout its entire lifecycle. The method and results could provide new insight into muscle development as well as treating damaged muscles and heart ...

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FLAM-seq: the full picture of messenger RNA and their tails

19-Aug-2019

Researchers in MDC’sBerlin Institute for Medical Systems Biology(BIMSB)have developed atoolenablingaccurate sequencing ofmessenger RNA along withtheirtails for the first time.ProfessorNikolausRajewskyand his team described this new tool, called full-length poly(A) and mRNA ...

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