Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of fat in the liver with an insulin resistance due to causes other than alcohol intake. NAFLD includes a spectrum of liver diseases from simple steatosis (“non-progressive” and reversible) to non-alcoholic steato ... more
Novel sensor implant radically improves significance of NMR brain scansResearchers present a new method that shows single neuron data
Illustration of the nuclear magnetic resonance (NMR) needle in the brain tissue
A team of neuroscientists and electrical engineers from Germany and Switzerland developed a highly sensitive implant that enables to probe brain physiology with unparalleled spatial and temporal resolution. Now published in Nature Methods, they introduce an ultra-fine needle with an integrated chip that is capable of detecting and transmitting nuclear magnetic resonance (NMR) data from nanoliter volumes of brain oxygen metabolism. The breakthrough design will allow entirely new applications in the life sciences.
The group of researchers led by Klaus Scheffler from the Max Planck Institute for Biological Cybernetics and the University of Tübingen as well as by Jens Anders from the University of Stuttgart identified a technical bypass that bridges the electrophysical limits of contemporary brain scan methods. Their development of a capillary monolithic nuclear magnetic resonance (NMR) needle combines the versatility of brain imaging with the accuracy of a very localized and fast technique to analyze the specific neuronal activity of the brain.
“The integrated design of a nuclear magnetic resonance detector on a single chip supremely reduces the typical electromagnetic interference of magnetic resonance signals. This enables neuroscientists to gather precise data from minuscule areas of the brain and to combine them with information from spatial and temporal data of the brain´s physiology,” explains principal investigator Klaus Scheffler. “With this method, we can now better understand specific activity and functionalities in the brain.”
According to Scheffler and his group, their invention may unveil the possibility of discovering novel effects or typical fingerprints of neuronal activation, up to specific neuronal events in brain tissue.
“Our design setup will allow scalable solutions, meaning the possibility of expanding the collection of data from more than from a single area – but on the same device. The scalability of our approach will allow us to extend our platform by additional sensing modalities such as electrophysiological and optogenetic measurements,“ adds the second principal investigator Jens Anders.
The teams of Scheffler and Anders are very confident that their technical approach may help demerge the complex physiologic processes within the neural networks of the brain and that it may uncover additional benefits that can provide even deeper insights into the functionality of the brain.
With their primary goal to develop new techniques that are able to specifically probe the structural and biochemical composition of living brain tissue, their latest innovation paves the way for future highly specific and quantitative mapping techniques of neuronal activity and bioenergetic processes in the brain cells.
- magnetic resonance
Conventional light microscopes cannot distinguish structures when they are separated by a distance smaller than, roughly, the wavelength of light. Superresolution microscopy, developed since the 1980s, lifts this limitation, using fluorescent moieties. Scientists at the Max Planck Institute ... more
It is the the dream of every molecular geneticist: an easy-to-use program that compares data sets from different cellular conditions, identifies enhancer regions and then assigns them to their target genes. A research team led by Professor Martin Vingron at the Max Planck Institute for Mole ... more
Entangled states of light allow for enhanced sensitivity in optical interferometry, a measurement technique in physics. Therefore, so-called path-entangled photon states in well-defined temporal pulses are required. So far, the generation of such states was possible only to a limited extent ... more
Physicists from the University of Stuttgart show the first experimental proof of a molecule consisting of two identical atoms that exhibits a permanent electric dipole moment. This observation contradicts the classical opinion described in many physics and chemistry textbooks. A dipolar mol ... more
The proton - one of the universal building-blocks of all matter - is even smaller than had previously been assumed. This is the result obtained at the Paul-Scherrer-Institut (PSI) in Villigen (Switzerland) by an international research team, including scientists from the Max Planck Institute ... more
- 1analytica 2020: The leading guide to the smart laboratory
- 2Using Gene Scissors to Detect Diseases
- 3Sartorius signs agreement to acquire select Danaher Life Science platform businesses
- 4First molecular movies at European XFEL
- 5Novel sensor implant radically improves significance of NMR brain scans
- 6Scientists design built-in controls for mini-chemical labs on a chip
- 7Novel mathematical framework provides a deeper understanding of how drugs interact
- 8Swiss Army Knife for Genome Research
- 9How graphene nanoparticles improve the resolution of microscopes
- 10Biologists examine sperm quality on the basis of their metabolism