Scientists can monitor biomolecular processes in live tissue by noninvasive optical methods, such as fluorescence imaging. However, the fluorescent dyes used for that purpose are often rather unstable, and photobleaching, lack of specificity, and poor pharmacokinetics are recurrent issues. US scient more
A team of researchers from the University of Illinois at Urbana-Champaign and Mayo Clinic have engineered a new type of molecular probe that can measure and count RNA in cells and tissue without organic dyes. The probe is based on the conventional fluorescence in situ hybridization (FISH) technique, more
Controlling the excited electronic states in luminescent systems remains a challenge in the development of fluorescent and phosphorescent dyes. Now, scientists in Japan have developed a unique organic fluorophore that changes its emission color without loss of efficiency when externally stimulated. more
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