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Chromatin originated in ancient microbes one to two billion years ago

Genomic and proteomic analysis reveals that the regulatory role of chromatin is a eukaryotic innovation

13-Jun-2022

In almost every human cell, two metres-long DNA has to fit within a nucleus that is just 8 millionths of a metre wide. Like wool around a spool, the extreme space challenge requires DNA to wrap around structural proteins called histones. This coiled genetic architecture, known as chromatin, ...

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Abundant ‘secret doors’ on human proteins could reshape drug discovery

Identification of hidden vulnerabilities on surface of ‘undruggable’ proteins could transform treatment of disease

11-Apr-2022

The number of potential therapeutic targets on the surfaces of human proteins is much greater than previously thought, according to the findings of a new study in the journal Nature. A ground-breaking new technique developed by researchers at the Centre for Genomic Regulation (CRG) in Barcelona ...

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Epigenetics key to daily production of 10 billion blood cells without mistakes

Study reveals a gene key for blood cell specialisation

10-Aug-2020

Just one in 2,000 bone marrow cells are hematopoietic stem cells (HSC), but these are the source of the ten billion blood cells humans make every day. In a new study published, researchers from the Centre for Genomic Regulation (CRG), in Barcelona, show that the epigenetic regulator Phf19 is ...

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Why are genetically identical individuals different? Ask your mum!

04-Dec-2017

Does the age of a mother influence the traits and characteristics of her progeny, and how? A team of scientists at the Centre for Genomic Regulation (CRG) in Barcelona have addressed these questions by studying tiny, genetically identical C. elegans worms. "Our lab has long been interested in ...

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First-ever blueprint of a minimal cell is more complex than expected

EMBL and CRG scientists reveal what a self-sufficient cell can't do without

01-Dec-2009

What are the bare essentials of life, the indispensable ingredients required to produce a cell that can survive on its own? Can we describe the molecular anatomy of a cell, and understand how an entire organism functions as a system? These are just some of the questions that scientists in a ...

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