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Early Detection by Tango

Fast, uncomplicated, and specific: diagnosis of prostate cancer from blood samples

24-Aug-2022

Early detection of prostate cancer, one of the most common types of cancer in men, is often achieved with PSA tests. However, this blood test for prostate-specific antigens gives many false positive results, causing unnecessary biopsies and overtreatment. In the journal Angewandte Chemie, a ...

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Tears instead of Blood

Sensor with separation capability: diagnosing jaundice using tear fluids

28-Jun-2022

Human tear fluids contain many proteins, metabolites, and other molecules whose concentrations change significantly with certain diseases. A research team has now developed a handy test kit for tears that can identify patients with jaundice. Their success is based on a hybrid sensor that ...

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Firefly Luminescence Reveals Pesticides

Luciferin synthesis and organophosphate detection by a luminescent enzymatic cascade

16-Mar-2022

A luminescence reaction modeled on fireflies can detect contamination with organophosphates with high sensitivity, ease, and low cost. At the center of this technology is a new enzymatic method for the synthesis of analogues of luciferin, the substance that makes fireflies glow. As reported by a ...

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Cellular Communication Agent

Tracking the NO signaling pathway

26-Aug-2021

Both nitric oxide (NO) and hydrogen sulfide (H2S) act as gaseous signaling molecules with similar physiological effects. Many of the critical questions about the interplay between these two gasotransmitters hinge on their chemical reactivity and the fleeting existence of HSNO, a key product of ...

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Overcoming False Optical Activity

Interference leads to inaccurate Raman spectroscopic analysis of vitamin B12

25-Aug-2021

Many natural products are complicated organic molecules. Despite this complexity, scientists are usually able to investigate them using spectroscopic techniques. However, a team of researchers has now discovered that care should be taken using Raman spectroscopy to analyze certain chiral ...

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Electrons Passed Around

Ultrafast charge transfer in Prussian blue analogues

23-Aug-2021

Photoinduced charge transfers are an interesting electronic property of Prussian blue and some analogously structured compounds. A team of researchers has now been able to elucidate the ultrafast processes in the light-induced charge transfer between iron and manganese in a manganese-containing ...

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A molecular shield for near-infrared fluorescent dyes

Stable and Functional Dyes for Near-Infrared Fluorescence Imaging of Living Subjects

05-Jun-2020

Scientists can monitor biomolecular processes in live tissue by noninvasive optical methods, such as fluorescence imaging. However, the fluorescent dyes used for that purpose are often rather unstable, and photobleaching, lack of specificity, and poor pharmacokinetics are recurrent issues. US ...

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Staining Cycles with Black Holes

Ultrafast repeated staining and destaining of cell samples for tumor diagnostics

27-Mar-2020

In the treatment of tumors, microenvironment plays an important role. It often contains immune cells that are so changed that they promote tumor growth. In the journal Angewandte Chemie, scientists have introduced a method by which cell samples from tumors and their surroundings can rapidly ...

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Amplification and imaging of microRNA as a biomarker to detect tumor development

Cancer Diagnostics

18-Mar-2020

A good indicator of dysregulation in live cells is a change in their RNA expression. MicroRNA (miRNA), a special type of RNA, is considered a biomarker for carcinogenic cells. A team of scientists from China has found a way to amplify miRNA in live tumor cells for bioimaging. As they report in ...

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Sensing Protein Wellbeing

Molecular probe maps misfolded proteome state in live cells

13-Jan-2020

The folding state of the proteins in live cells often reflect the cell’s general health. Australian scientists have developed a molecular probe that senses the state of the proteome—the entire set of the proteins—by measuring the polarity of the protein environment. The fluorescence signal of the ...

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