Scientists at Scripps Research have invented a way to image, across different tissues and with higher precision than ever before, where drugs bind to their targets in the body. The new method could become a routine tool in drug development. Described in a paper in Cell on April 27, 2022, th ... more
FEI and Scripps Research Institute Provide Open Source Code
Open Source License for Leginon Software Will Make Automated Image Acquisition Available to Entire Scientific Community
FEI and The Scripps Institute have announced that the Leginon(TM) software system, an advanced solution for automated control and image acquisition from a transmission electron microscope (TEM), will now be available to the global scientific community as open source code. The Leginon software was developed by Scripps with funding from the National Center for Research Resources, National Institutes of Health and has been marketed by FEI since 2003. It is most commonly used for Single Particle Analysis (SPA) applications, where three dimensional models of nanoscale particles are created.
The Leginon software enables TEM users to collect very large numbers of high quality images of macromolecules under low dose conditions. The automated system is integrated with a database that keeps track of all acquired images, the imaging parameters associated with them, as well as the relationship between images acquired from the same target at a variety of scales. The application helps improve throughput for single particle data acquisition, both by increasing the number of images acquired as well as the number of different specimens that can be imaged and analyzed.
"The relationship between FEI and our group at TSRI was critical to the initial development of Leginon as well as the subsequent rapid implementation of new features suggested by the user community," said Bridget Carragher, Director of the National Resource for Automated Molecular Microscopy, which is based at TSRI. Clint Potter, a Co- Director of the Resource added, "The generosity of FEI in releasing Leginon under an Open Source License ensures that the software can now continue to be developed by the scientific community for the benefit of everyone."
Leginon software is now available for download subject to the Apache Open Source License.
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Scripps Research scientists have solved a major problem in chemistry and drug development by using droplet-sized 'miniecosystems' to quickly see if a molecule can function as a potential therapeutic. As they report the new method will let researchers save critical time and funding by simult ... more
Thermo Fisher Scientific Inc. announced that it has completed its acquisition of FEI Company, Inc. a manufacturer of high-performance electron microscopy, for $107.50 per share in cash, or a total purchase price of approximately $4.2 billion. The completion of the transaction follows the re ... more
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