Agendia's MammaPrint shows significant agreement with other multi-gene breast cancer prognosis tests
In a publication in the New England Journal of medicine, Agendia's MammaPrint® 70 gene breast cancer prognosis test and three other multi gene tests are shown to be superior over conventional assessment of risk of future metastatic disease. This reinforces the reliability of multi-gene tests for breast cancer prognosis prediction. The authors conclude that, even though the multi gene tests have only minimal overlap in the genes used, they show a remarkable agreement in assigning patients to the same risk category. This is probably due to the fact that the different genes used track a common set of biological characteristics of the individual cancer, leading to a similar assessment of the risk of developing metastatic disease.
Dr. Charles Perou, senior author of the New England Journal of Medicine states in the publication that it is clear that these profiles provided significant additional information beyond that provided by grade (i.e. histological assessment of tumor aggressiveness). In a commentary in the same issue of the New England Journal of Medicine, Dr. Joyce O'Shaughnessy comments that multi-gene tests will alter medical practice such that in the future 30- to 50% fewer patients with ER-positive breast cancer will receive adjuvant chemotherapy.
Other news from the department business & finance
Most read news
More news from our other portals
Last viewed contents
Water distribution in the fuel cell made visible in 4D - The analysis opens new possibilities for more efficient and thus more cost-effective fuel cells
New deep learning algorithm can pick up genetic mutations and DNA mismatch repair deficiency in colorectal cancers more efficiently - The findings open up the possibility to select patients likely to benefit from targeted therapies at lower costs and with quicker turnaround times as compared to current methods
VWR International Acquires INTERNATIONAL P.B.I. S.p.A. - VWR strengthens its position in Italy
Molecular imaging hack makes cameras 'faster'
DataApex audited for ISO 9001 standards
Brain imaging gives new insight into mental disorders
Pain sensors specialized for specific sensations
Corona research at BESSY II: Two days of measuring operation to find the right key
Sensor to search for artery hardening compounds in blood
Potent, puzzling and (now less) toxic: How antifungal drug works
Merck’s new spin-off to focus on infertility treatment
