Chondrogene reports on blood-based prostate cancer diagnostic test development
Prostate cancer is scored using a grading system developed by Dr. Donald Gleason in 1974 that measures prostate tumour aggressiveness. The Gleason score ranges between 2 and 10, with 10 being the most aggressive form of prostate cancer. Most experts would agree that any cancer with a Gleason score of 7 or above has a high probability of spreading, leading to mortality and therefore should be treated aggressively.
To date, the Company has collected over 500 blood samples in North America and Asia from patients with elevated PSA levels, who have also undergone prostate biopsy and Gleason scoring. ChondroGene has used these samples to identify blood-based biomarker sets that will form the basis of molecular diagnostic tests for the detection of aggressive forms of prostate cancer.
In one study, ChondroGene used a four gene biomarker set, in combination with PSA levels, to identify patients with aggressive forms of prostate cancer. The test was able to discriminate patients with prostate cancer having Gleason scores greater than 7 from controls with sensitivities greater than 90%. The Company is accruing additional blood samples from patients with prostate cancer. The continued accruals shall enable the Company to further validate these initial biomarker sets with blinded studies prior to formal development of a molecular diagnostic kit.
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Topic world Diagnostics
Diagnostics is at the heart of modern medicine and forms a crucial interface between research and patient care in the biotech and pharmaceutical industries. It not only enables early detection and monitoring of disease, but also plays a central role in individualized medicine by enabling targeted therapies based on an individual's genetic and molecular signature.
Topic world Diagnostics
Diagnostics is at the heart of modern medicine and forms a crucial interface between research and patient care in the biotech and pharmaceutical industries. It not only enables early detection and monitoring of disease, but also plays a central role in individualized medicine by enabling targeted therapies based on an individual's genetic and molecular signature.