When we think of ions, we usually think of single atoms that have lost or gained some electrons, but entire molecules can also become ions. In a new publication that was highlighted as an Editor’s Suggestion in Physical Review Letters, physicists from the University of Amsterdam, QuSoft and ... more
New mechanism that leads to inflammation in rheumatoid arthritis discovered
New research findings suggest that synovial CD4+ T cells that produce IL-21 contribute to joint inflammation by activating synovial fibroblasts in rheumatoid arthritis patients. Understanding the mechanisms of inflammation in rheumatoid arthritis is important for the design of new therapies for this disease.
"Patients with rheumatoid arthritis with active disease (inflamed joints) have difficulty for instance in using their hands and also with walking," said Maria Cristina Lebre, Ph.D., a researcher involved in the work from the Academic Medical Center at the University of Amsterdam, Department of Experimental Immunology in Amsterdam, The Netherlands. "New targeted therapies such as that proposed in this study (decrease in inflammation) will certainly improve the quality of life of patients by increasing their mobility."
Using a novel isolation method, scientists isolated T cells from synovial fluid from patients with rheumatoid arthritis that produced IL-21 and TNF and compared these with cells that did not produce this cytokine. When cells that produced IL-21 were put in culture with synovial fibroblasts (which are the main contributors to joint inflammation in rheumatoid arthritis), they induced the production of proinflammatory cytokines by these synovial fibroblasts, and cells that do not produce IL-21, did not demonstrate this same outcome. The results of this study suggest that a combined therapy targeting IL-21 and TNF might be beneficial for patients that do not respond to anti-TNF therapy or other current therapies. This research could also have an impact on other diseases such as systemic lupus erythematosus, systemic sclerosis and Crohn's disease.
"Patients with rheumatoid arthritis often become refractory to treatment provoking the need to try different drugs targeting different pathways," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "The identification of a new inflammatory target in rheumatoid arthritis holds promise for better treatment for these patients and perhaps those with other autoimmune or inflammatory diseases."
- rheumatoid arthritis
- systemic sclerosis
- systemic lupus eryt…
- inflammatory disease
- Morbus Crohn
- Crohn's disease
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Developing tiny probes for research and brain-related medical applications – that is the goal of the project NeuroSeeker, launched in February 2013 with a kick-off event in Leuven. The interdisciplinary project pools the expertise of ten partner institutions from Europe and Canada. The Univ ... more
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