29-Jun-2018 - University of Science and Technology of China

Structure of S. agalactiae toxin identified

Streptococcus (S.) agalactiae (contains the CAMP factor) is a round bacterium that could cause severe invasive infections. Biologists team led by Prof. JIN Tengchuan from University of Science and Technology of China of Chinese Academy of Sciences and Dr. Eric Brefo-Mensah from the University of Waterloo revealed the structure of S. agalactiae CAMP factor and the mechanism behind for the first time.

By utilizing X-ray diffraction technique, researchers reported the structural fold of S. agalactiae CAMP factor is composed of 5+3 helix bundles, where the N-terminal 5 helix bundle is believed to be responsible for membrane permeabilization and the C-terminal 3 helix bundle is likely responsible for host receptor binding. Besides, the C-terminal domain is revealed to inhibit the activity of both full-length toxin and its N-terminal domain.

The researchers also observed that the linker region has a conserved DLxxxDxAT sequence motif, which is required for CAMP factor's co-hemolytic activity. The results helped clarify the molecular mechanism of S. agalactiae's co-hemolytic activity.

What the researchers illustrated may assist in the screening of anti-CAMP virulent factor drugs and inspire more to reveal the nature of the interaction between proteins and biofilms.

University of Science and Technology of China

Request information now

Recommend news PDF version / Print

Share on

Facts, background information, dossiers
  • biologists
  • biological chemistry
  • proteins
  • Streptococcus agalactiae
  • Streptococcus
  • X-ray diffraction analysis
More about University of Science and Technology of
  • News

    Super-resolved imaging of a single cold atom on a nanosecond timescale

    The team of academician GUO Guangcan of University of Science and Technology of China (USTC) of the Chinese Academy of Sciences has made important progress in the research of cold atom super-resolution imaging. The team achieved super-resolution imaging of a single ion in an ion trap system ... more

    Diamond ring architecture of a protein complex

    Just as diamond ring is needed in marriage, NuA4/Tip60, a complex with diamond ring architecture, is required for regulatory and repairing processes. Prof. CAI Gang and Prof. Jacques Côté's team reports the 4.7 Å structure of the yeast NuA4/TIP60 complex, which elucidates the detailed archi ... more

    Scientists realize quantum simulation of the Unruh effect

    Quantum mechanics and relativity theory are two pillars of modern physics. With their amalgamation, many novel phenomena have been identified. For example, the Unruh effect is one of the most significant outcomes of the quantum field theory. This effect serves as an important tool to invest ... more