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New microscopy method resolves fluorescent molecules with resolution at the nanometer scale

22-Mar-2021

Scientists working with Stefan Hell at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen and the Heidelberg-based MPI for Medical Research have developed another light microscopy method, called MINSTED, which resolves fluorescently labeled details with molecular sharpness. ...

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Crystal structures in super slow motion

Researchers first to succeed in filming a phase transition with extremely high spatial and temporal resolution

26-Jan-2021

Laser beams can be used to change the properties of materials in an extremely precise way. This principle is already widely used in technologies such as rewritable DVDs. However, the underlying processes generally take place at such unimaginably fast speeds and at such a small scale that they ...

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World record resolution in cryo-electron microscopy

Novel technique visualizes individual atoms in a protein with cryo-electron microscopy for the first time

23-Oct-2020

A crucial resolution barrier in cryo-electron microscopy has been broken. Holger Stark and his team at the Max Planck Institute (MPI) for Biophysical Chemistry have observed single atoms in a protein structure for the first time and taken the sharpest images ever with this method. Such ...

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Dissecting protein assemblies

New molecular details from mitochondria

14-Aug-2020

Super-resolution MINFLUX nanoscopy, developed by Nobel laureate Stefan Hell and his team, is able to discern fluorescent molecules that are only a few nanometers apart. In an initial application of this technique to cell biology, researchers led by Stefan Hell and Stefan Jakobs have now optically ...

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Virus multiplication in 3D

16-Dec-2019

Vaccinia viruses serve as a vaccine against human smallpox and as the basis of new cancer therapies. Two studies now provide fascinating insights into their unusual propagation strategy at the atomic level. For viruses to multiply, they usually need the support of the cells they infect. In many ...

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Watching Molecular Machines at Work

15-Aug-2016

An international team of scientists from Austria, Germany and the US has combined newly developed techniques in electron microscopy and protein assembly to elucidate how cells regulate one of the most important steps in cell division. When one cell divides into two - that is how all forms of life ...

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Detailed structure of cell’s garbage disposal unit reveals surprise in how it is targeted by cancer drugs

Every atom counts

08-Aug-2016

Malignant cancer cells not only proliferate faster than most healthy cells in our bodies. They also generate more “junk”, such as faulty and damaged proteins. This makes cancer cells inherently more dependent on the most important cellular garbage disposal unit, the proteasome, which degrades ...

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Sharp images from the living mouse brain

Max Planck scientists in Goettingen have for the first time made finest details of nerve cells in the brain of a living mouse visible

08-Feb-2012

To explore the most intricate structures of the brain in order to decipher how it functions – Stefan Hell's team of researchers at the Max Planck Institute for Biophysical Chemistry in Göttingen has made a significant step closer to this goal. Using the STED microscopy developed by Hell, the ...

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The 2011 Körber Prize goes to Stefan Hell

With a groundbreaking idea the physicist has overcome the diffraction resolution barrier in optical microscopy

08-Jul-2011

Prof. Dr. Dr. h. c. Stefan Hell of the Max Planck Institute for Biophysical Chemistry in Göttingen is to receive the 2011 Körber European Science Prize endowed with 750,000 euros for his pioneering discoveries in the field of optics. Every year, the Körber Prize is awarded to an outstanding ...

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Written in Red

Red-Emitting Dyes for Optical Microscopy and Nanoscopy

08-Jul-2010

Far-field optical nanoscopy methods, especially STED (stimulated emission depletion), pose very strict and, at times, contradictory requirements on the utilized fluorescent markers. Photostable fluorescent dyes that absorb in the red optical region are indispensable as labels for various micro- ...

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