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Monitoring gene activities in living cells

Cell Biopsy instead of cell lysis

19-Aug-2022

Researchers from ETH Zurich and EPFL are expanding the emerging field of single-​cell analysis with a ground-​breaking method: Live-​seq makes it possible to measure the activity of thousands of genes in a single cell without having to isolate and destroy it. Modern biology is increasingly ...

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Tracking chirality in real time

“These ground-breaking experiments show that time-resolved circular dichroism is uniquely suited to capture the molecular motion that drives many (bio)chemical processes”

01-Jun-2022

Scientists at EPFL have developed a new laser-based technique that can measure ultrafast changes in the structural symmetry of molecules, called chirality, tracking their conformational shifts in real time. In a collaboration with researchers from the Universities of Geneva and Pisa, the ...

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Molecular device turns infrared into visible light

Breakthrough ushers in a new class of compact sensors for thermal imaging and chemical or biological analysis

06-Dec-2021

Light is an electromagnetic wave: it consists of oscillating electric and magnetic fields propagating through space. Every wave is characterized by its frequency, which refers to the number of oscillations per second, measured in Hertz (Hz). Our eyes can detect frequencies between 400 and 750 ...

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Carbyne – an unusual form of carbon

International team of researchers investigates optical band gap of carbon compound

13-Nov-2020

Which photophysical properties does carbyne have? This was the subject of research carried out by scientists at FAU, the University of Alberta, Canada, and the Ecole Polytechnique Fédérale de Lausanne in Switzerland, which has led to a greater understanding of the properties of this unusual form ...

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Visualizing chemical reactions

On the way to synthetic fuels

10-Jan-2020

Researchers at the joint EPFL-Empa lab in Sion have developed a reactor system and an analysis method that has allowed them to observe the real-time production of synthetic natural gas from CO2 and H2 for the first time. Infrared (IR) thermography is used to determine the temperature of humans ...

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Predicting a protein's behavior from its appearance

11-Dec-2019

Proteins are the building blocks of life and play a key role in all biological processes. Understanding how they interact with their environment is therefore vital to developing effective therapeutics and the foundation for designing artificial cells. Researchers at the Laboratory of Protein ...

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On the way to nanotheranostics

10-Jul-2019

Theranostics is an emerging field of medicine whose name is a combination of "therapeutics" and "diagnostics". The idea behind theranostics is to combine drugs and/or techniques to simultaneously - or sequentially - diagnose and treat medical conditions, and also monitor the response of the ...

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New chemical tools to modify and study biomolecules

08-Jul-2019

Understanding the structure and metabolism of cells and living organisms is essential for the development of new drugs and diagnostics. The availability of chemical tools that allow scientists to edit biomolecules, like proteins, with atom-level resolution have greatly contributed to the progress ...

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Chirality in 'real-time'

Circular dichroism in the deep ultraviolet

11-Jan-2019

In nature, certain molecules with the same chemical composition, can exist in two different shapes that are mirrors images of each other, much like our hands. This property is known as "chirality" and molecules with different chirality are called enantiomers. Enantiomers can exhibit entirely ...

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Anti-aging molecule NAD+ gets a boost from blocking an enzyme

25-Oct-2018

Nicotinamide adenine dinucleotide (NAD+) is a major player in nutrition today. Studies have shown that NAD+ concentrations decrease during aging and that recovering the body's levels of NAD+ can prolong both health span and even life span, making it the focus of much research in nutritional ...

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