Merck has acquired BSSN Software, a Darmstadt, Germany-based laboratory informatics company that makes data more readily accessible for ease of integration, collaboration, analysis and long-term archiving. Financial details were not disclosed. “BSSN Software and the capabilities that it bri ... more
David Alsteens Receives 2019 Heinrich Emanuel Merck Award for Analytical Science
Merck presented Professor David Alsteens (33), Catholic University of Louvain (UCLovain), Louvain-la-Neuve, Belgium with the 2019 Heinrich Emanuel Merck Award for Analytical Science. The award ceremony took place during the analytical conference Euroanalysis at Istanbul University in Turkey.
“With his groundbreaking investigations revealing the molecular mechanisms established by viruses to hijack the cellular barrier and enter the cell, David Alsteens joins a prominent group of innovative Heinrich Emanuel Merck Award winners,” said Klaus Griesar, head of Science Relations at Merck. “Perhaps in the future, his research could be used to develop a new tool to quantify the effects of molecules that interfere with the entry of viruses, and thus support the development of new drugs against viral infections.”
Alsteens has made a mark internationally through his work on the nanomechanics of living systems. He has conducted groundbreaking research on nanomechanical mapping of the first binding steps of a virus to animal cells using a combination of atomic force microscopy (AFM) with confocal microscopy. Alsteens has described his inventions in one granted patent and in a second filed patent.
The winner is currently Research Associate at the Fund for Scientific Research and Professor at the Faculty of Bioscience Engineering at UCLouvain. He completed his Ph.D. thesis in nanobiotechnology at the Institute of Condensed Matter and Nanosciences of the UCLouvain in 2011and spent two years at ETH Zurich in Basel, Switzerland, as a post-doc.
The cell plasma membrane is a highly complex interface between the cell’s interior, the cytoplasm, and the extracellular environment. It serves as a barrier as well as a versatile and essential signaling interface. Within this context, probing how ligands (peptides, drugs or viruses) interact with native membrane receptors in physiologically relevant conditions is of fundamental interest in many disciplines of biology, including cell biology, molecular biology, structural biology, biochemistry, and biophysics.
To address the question of how receptors in the cell wall interact with biomolecules (for example on the surface of a virus) Alsteens introduced the use of force-distance curve-based AFM, a technique to simultaneously image mammalian cells and quantify their dynamic binding properties to specific ligands. In addition, he recently combined the methodology with confocal microscopy to simultaneously monitor the cellular characteristics, for example cell state, distribution of cell surface receptors.
Alsteens’ breakthrough was to simultaneously record the energy landscape of ligand-binding to specific receptors with high-resolution AFM imaging of cell surface in native conditions.
Since 1988, the Heinrich Emanuel Merck Award for Analytical Science has been recognizing scientists under the age of 45 whose work focuses on new methods in chemical analysis and the development thereof in applications aimed at improving the quality of human life, for example in fields such as life sciences, environmental protection and biosciences.
Merck and Rigaku Corp., Tokyo, Japan, have signed a joint development agreement to develop lab consumables based on crystalline sponge technology, which determines the absolute chemical structure of organic molecules and enables X-ray crystallography without crystallization of the analyte. ... more
Merck generated very strong organic sales growth in the third quarter of 2018. However, this was impacted by negative exchange rate effects. Despite organic growth, EBITDA pre of the Group also declined in comparison with the year-earlier quarter owing to strong negative foreign exchange ef ... more
See how premium quality, unique packaging, and new 2D data matrix labels make EMSURE® inorganics and solvents the smartest choice for precise analysis. more
Buffers are an essential part of laboratory experiments. The pHast Pack™ ready-to-use buffers are specially designed to simplify your work. Simply mix the precisely pre-weighed packets with distilled water for quick results that are reliably reproducible again and again. By saving time, eff ... more
Scientists at VIB-KU Leuven have identified a new mechanism that impacts tumor growth. The typical lack of oxygen in tumors doesn't only stimulate proliferation, but also offsets the important role of the protein PHD2 as 'cancer cell killer'. A possible solution lies in blocking the enzyme ... more
Specific regions of the brain are specialized in recognizing bodies of animals and human beings. By measuring the electrical activity per cell, scientists from KU Leuven, Belgium, and the University of Glasgow have shown that the individual brain cells in these areas do different things. Th ... more
Colorectal cancer is the third most common form of cancer globally and the second most common cause of cancer deaths. The chance of a cure is high if the cancer is detected early enough, but early detection is not a given. Researchers from VIB and KU Leuven - together with various European ... more
- 1Virtual screening for active substances against the coronavirus
- 2analytica 2020 is postponed
- 3Thermo Fisher Scientific to Acquire QIAGEN
- 4Smartphone lab finds coronavirus in saliva
- 5The digital laboratory live and tangible
- 6analytica 2020: Bioanalysis for personalized medicine
- 7Roche’s cobas SARS-CoV-2 Test to detect novel coronavirus receives FDA Emergency Use Authorization
- 8Innovative ways to battle Parkinson’s disease
- 9Abbott Receives FDA Emergency Use Authorization and Launches Test to Detect Novel Coronavirus
- 10Using oxygen to make cancer visible