The human cardiac voltage-gated sodium channel (Nav1.5) plays a critical role in maintaining regular heartbeats. Mutations in Nav1.5 cause life-threatening heart rhythm disorders (arrhythmias). Nav1.5 is sensitive to the calcium-ion sensor protein calmodulin (CaM); however, the exact mechan ... more
Evolution of a deadly virusGenomic sequences reveal that Florida is a major source of a mosquito-borne virus
Infections caused by the mosquito-borne eastern equine encephalitis virus (EEEV) are severe and have high mortality rates for horses - 90 percent - and humans - 33 percent, with significant brain damage in most human survivors.
Florida has been hypothesized to be the source of EEEV epidemics, but little is known about the evolutionary characteristics of the virus.
Suman Das, PhD, and colleagues have now sequenced and analyzed complete genomes of 433 EEEV strains collected within the United States from 1934 to 2014.
They report that EEEV appears to evolve relatively slowly and that strains have long-term persistence and higher genetic diversity in Florida, compared to strains from northeastern states such as New York and Massachusetts.
The findings support a model in which Florida is a major source of EEEV, with viruses that are endemic in Florida migrating and seeding outbreaks in northern states. The results may have important implications for the control and prevention of other mosquito-borne viruses in the Americas.
Yi Tan et al.; "Large scale complete genome sequencing and phylodynamic analysis of eastern equine encephalitis virus reveal source-sink transmission dynamics in the United States"; J Virology; 2018
- eastern equine ence…
- genomic sequencing
MCL-1 is a member of the BCL-2 family of proteins important for blocking apoptosis, or programmed cell death. Many types of cancer cells escape the body’s effort to kill them by overexpressing MCL-1. However, new evidence from Vanderbilt University researchers indicates that MCL-1 also help ... more
Vanderbilt researchers have established a new measure of resilience to cognitive impairment in people with asymptomatic Alzheimer’s disease. They essentially flipped the standard approach used by researchers when mining the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database, said T ... more