VTT Technical Research Centre of Finland has developed a mobile app and thumb-size device that help to prevent cerebral infarctions at an early stage, during asymptomatic atrial fibrillation. The mobile device, which detects arrhythmia (irregular heartbeat) has been tested with excellent re ... more
VTT and GE Healthcare developing novel biomarkers to predict Alzheimer’s disease
Scientists from VTT Technical Research Centre of Finland in collaboration with the University of Eastern Finland have recently discovered a serum biochemical signature which predicts progression to Alzheimer’s disease months or even years before the first symptoms of the disease occur. The goal of the new collaboration between VTT and GE Healthcare is to validate this biomarker in a large patient cohort as well as to discover novel biomarker candidates.
Early detection of prodromal AD is vital both for assessing the efficacy of potential AD therapeutic agents as well as new disease modifying therapies are most likely to be effective when initiated during the early stages of disease. The elucidation of early metabolic pathways associated with progression to Alzheimer’s disease may also help in identifying new therapeutic avenues.
In 2010 GE Healthcare entered into “biosignatures initiative” alliance with Janssen Pharmaceutica N.V. (Janssen) to develop diagnostic biosignatures for pre-symptomatic identification of AD. As part of this programme, VTT will apply serum metabolite profiling to validate their recently discovered biochemical signature, as well as to discover novel biomarker candidates predictive of progression to AD.
VTT’s research professor Matej Orešič said: “We are excited about the prospect of collaborating with GE Healthcare to accelerate its research programs and to further develop our biomarker towards a clinical assay applicable in healthcare setting. VTT has over the past years built unique metabolomics and systems biology platforms and acquired vast amount of knowledge on metabolic profiles and pathways in human health and disease, which allow us to identify disease-specific biochemical signatures and pathways. We believe that integration of metabolomics into the GE’s and Janssen’s biosignatures initiative will lead to better tools for early detection of AD and may also lead to better therapeutic options.”
- GE Healthcare
- VTT Technical Resea…
- Alzheimer's disease
Some breweries have taken to resurrecting the flavors of ages past. Adventurous beer makers are extrapolating recipes from clues that archeologists have uncovered from old and even ancient brews found at historical sites. Now scientists have analyzed some of the oldest preserved beer sample ... more
VTT Technical Research Centre of Finland has developed an innovative magnetometer that can replace conventional technology in applications such as neuroimaging, mineral exploration and molecular diagnostics. Its manufacturing costs are between 70 and 80 per cent lower than those of traditio ... more
GE Healthcare, a unit of General Electric Company, announced that it has entered into a Strategic Alliance Agreement with FUJIFILM Corporation. Under the alliance, Fujifilm will develop, manufacture and supply advanced biomolecular imaging systems to GE Healthcare. The products will be sold ... more
Tecan and GE Healthcare are working together to bring increased quality and efficiency to process development. The collaboration between the two suppliers focuses on high throughput screening of protein purification conditions, using the combination of Tecan’s Freedom EVO® automated worksta ... more
GE Healthcare, a unit of General Electric Company announced that it has completed the acquisition of Whatman plc, a global supplier of filtration products and technologies. The acquisition expands GE Healthcare's offering for life science research and biopharmaceutical manufacturing. GE H ... more
Protein A-based chromatography is the primary method used to purify monoclonal antibodies (MAbs). Despite much discussion about the high purchase costs, protein A medium (resin) still is a cost-efficient alternative to most other purification techniques. Over the past decade, there has b ... moreWebinarOn-Demand
Significant improvements in a chromatography workflow can be achieved with small changes and proactive choices. Before starting protein purification, it is important to define your requirements and objectives. These may include outlining the required purity, activity and the quantity of th ... moreWebinarOn-Demand
A conversation with Biogen Idec and GE Healthcare Life Sciences. The increasing pressures from global competition plus the need to reduce manufacturing costs are driving the biopharmaceutical industry to improve operational excellence in development and manufacturing. Continuous downstream ... more
- 1A new role for an old protein in breast cancer
- 2Protein-folding simulations sped up
- 3Microscope using UV instead of visible light emerging as diagnostic tool
- 4Physicists propose a new method for monitoring nuclear waste
- 5Nature's toughest substances decoded
- 6First DNA sequence from a single mitochondria
- Imperial and Tsinghua University launch seed fund for 'ambitious collaborations'
- Analytik Jena and BAM agree to cooperate in research
- Hummingbird Diagnostics and Saarland University Collaborate in Early Disease ...
- Google provides open source library for quantum chemistry
- Successful online marketing right from the start
- New microscope sets a record for visualizing surface wetting properties
- Low-cost material for lighting and diagnostics produces white light imitating sunlight
- A mobile device developed by VTT detects irregular heartbeats
- Brainshake closes €3.5M to advance regulatory approval of blood analysis service
- REACH is the dominant driver for substitution - more action is needed