5 Current white paper about the topic mass spectrometry

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Field-Flow Fractionation - The Universal Separation Principle for Particle and Macromolecule Characterization

22-09-2010

High molecular weight polymers, bio molecules or particles in a range of a few nanometers up to several microns are more and more important in science and technology. Many applications are based on the specific properties of these materials. For this reason, an exact knowledge of the molar mass or particle sizes distribution is essential for later application as well as for optimization of the production processes or quality control. In addition the knowledge about the chain structure of macromolecules or biopolymers as well as about the shape of particles is often necessary. For this reason those samples, which often can be very complex systems, have to be separated according to parameters such as e.g. hydrodynamic volume or molecular weight. After the separation process the resulting narrow dispersed fractions are detected with different techniques....

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Enzymatic Protein Digest for Mass-spectrometric Analysis

26-09-2007

The main focus in proteomic studies is on the identification of proteins in given biological samples. Proteins isolated and separated from a given sample (e.g., whole cell lysates, blood or tissue, protein complexes) by immunoprecipitation or affinity chromatography or two-dimensional electrophoresis must be proteolytically cleaved in the course of sample preparation for identification and characterization. A reproducible cleavage pattern of digested proteins is a prerequisite for the unambiguous identification of these proteins by mass spectrometry (MS)....

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The Determination of Hazardous Substances According to RoHS and WEEE Directives

28-08-2005

1st July 2006 is an important deadline for the electro- and electronics industries. This date bans hazardous substances like lead, cadmium, mercury, hexavalent chromium and polybrominated biphenyls and diphenyl ethers from electro- and electronic equipment. This restriction, even though in discussion since 1991, has become more and more important from year to year because of tons of electronic waste releasing toxic substances which are accumulated in the environment, the food chain and all human beings. In order to enforce the substances ban and the limitation or substitution of hazardous components, elemental analysis is obviously the most important control measure for monitoring limiting values. This requires precise analytical systems such as X-ray fluorescence, ICP- and atomic absorption spectrometers. These instruments are able to detect trace concentrations of hazardous compounds - for example cadmium, using an atomic absorption spectrometer in the flame atomization mode up to 0.1 mg/L, or using the di...

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Accurate Mass and TIPTM: Two Dimensions for Elemental Composition Determination: microTOFTM Featuring Unique TIPTM

10-03-2005

The ESI-TOF mass spectrometers micrOTOF and micrOTOF focus do not only provide accurate mass measurements but additionally describe the True Isotopic Pattern TIPTM. For molecular formula generation this unique combination significantly reduces the number of possible formula candidates and the elemental composition of compounds with molecular weights far higher than 500 Da can unequivocally be determined...

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Half a Century of Chromatography with Agilent and Predecessors

One Century of Chromatography with Twsett (1903)

01-10-2004

Twsett originated the chromatography with his work about the separation of chlorophyll in 1903. For some time it was relatively quite around this new technology. Exceptions were the workings of Kuhn and Lederer (1931) as well as of Hesse (1936 and 1942). A break through succeeded to E. Cremer during the 40ies, but hardly considered caused by the war events, what however in the years 1950/51 by the conception of the gas chromatography suddenly changed and involved a rapid development...

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