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True Surface Microscopy - Chemical Imaging along with large area optical profiling

WITec's exclusive new True Surface Microscopy option makes it possible to perform confocal imaging measurements parallel with and guided by large area topographic scans more

Win a Spectra Database or Your Favorite Sample Preparation Tool

Win a Spectra Database or Your Favorite Sample Preparation Tool - Stop By Our Booth On Analytica 2012! more

Tabletop Microscope from Hitachi offers improved performance and a smaller footprint

The TM3000 offers significantly improved performance, including magnification up to 30,000x and better resolution, in a unit that occupies 20% less space more

News microscopy

• Tiny tool can play big role against tuberculosis

  A tiny filter could have a big impact around the world in the fight against tuberculosis. Using the traditional microscope-based diagnosis method as a starting point, a University of Florida lung disease specialist and colleagues in Brazil have devised a way to detect more cases of the bacterial inf more

• ORNL microscopy inspires flexoelectric theory behind 'material on the brink'

  Electron microscopy, conducted as part of the Shared Research Equipment (ShaRE) User Program at the Department of Energy's Oak Ridge National Laboratory, has led to a new theory to explain intriguing properties in a material with potential applications in capacitors and actuators. A research team le more

• Winner of the WITec Paper Award 2011 Announced
  

  The winner of the WITec Paper Award 2011 has been announced. This year the award goes to Diedrich A. Schmidt, North Carolina A&T State University, USA, Taisuke Ohta and Thomas E. Beechem both from the Sandia National Laboratories, Albuquerque, New Mexico, USA for their paper: “Strain and charge carr more

White papers microscopy

• Field-Flow Fractionation - The Universal Separation Principle for Particle and Macromolecule Characterization
  

  High molecular weight polymers, bio molecules or particles in a range of a few nanometers up to several microns are more and more important in science and technology. Many applications are based on the specific properties of these materials. For this reason, an exact knowledge of the molar mass or particle sizes distribution is essential for later application as well as for optimization of the production processes or quality control. In addition the knowledge about the chain structure of macromolecules or biopolymers as well as about the shape of particles is often necessary. For this reason those samples, which often can be very complex systems, have to be separated according to parameters such as e.g. hydrodynamic volume or molecular weight. After the separation process the resulting narrow dispersed fractions are detected with different techniques. more

• Efficient Transfection of Primary Human Skeletal Myoblasts Using FuGENE® HD Transfection Reagent
  

  Transfection of cells is one of the main techniques used to influence gene expression. Most primary cells and human skeletal myoblasts (SkMC) in particular are very difficult to transfect, whereas for cell lines such as C2C12, many suitable transfection reagents and protocols are available. Few publications report successful transfection of human primary myoblasts using non-viral systems [1,2,3]. These methods include cationic lipids such as phosphono­lipids, electroporation, and a combination of liposome and adenoviral associated proteins. But transfection efficiency is low and often is a compromise between toxicity of the reagents and transfection efficiency. more

• Particle shape - an important parameter in pharmaceutical manufacturing
  

  The advent of rapid and reliable measurement technologies, together with the FDA's PAT (Process Analytical Technologies) initiative, has increased the use of particle shape analysis within the pharmaceutical industry. Particle shape, like particle size which is routinely measured and controlled, can directly influence product performance and its measurement can lead to improved process and product understanding. Here we consider the importance of particle shape measurement for the pharmaceutical industry, with reference to the aims of the PAT initiative, and highlight the modern image analysis techniques available for sensitive size and shape characterization. more

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