The Nexera XS inert system offers ideal conditions for the separation of biomolecules, by combining the elevated pressure tolerance of a UHPLC system with complete inertness of the sample flow path. This is ensured by the absence of wetted metal surfaces and offers ultra-high resistance to corrosion. In addition, the Nexera XS inert comprise user-friendly finger-tight, zero-dead-volume tubing connectors that withstand pressure up to 105 MPa for fast UHPLC analysis. Optional switching valves used for method scouting or trap-and-elute analysis are designed to inhibit metal adsorption. The also optional pHM-40 mobile phase monitor continuously tracks any changes in pH in real time, making the Nexera XS inert the ultimate tool for ion-exchange or size-exclusion chromatography, where mobile phase pH can strongly affect chromatographic separation. The portfolio is completed by a wide range of consumables (e.g., columns, vials) that feature unique technologies for inhibiting sample adsorption.