283 Current news about the topic mass spectrometry


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Medicines with Sugar Chains

Native top-down mass spectrometry reveals role of glycans in protein oligomers


Many proteins contain patterns of sugar molecules (glycans) and are made of several aggregated subunits. This glycosylation and oligomerization has a decisive influence on protein function and must be considered in biopharmaceutical development. In the journal Angewandte Chemie, a British team ...


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New collaboration between Shimadzu and the University Medical Center Göttingen

Shimadzu and UMG team up to develop new clinical LC-MS methods for more rapid and flexible TDM analysis


Shimadzu is embarking on a new collaboration with the University Medical Center Göttingen (UMG). UMG is one of Germany's leading university medical facilities. The collaboration will focus on the development of new clinical laboratory methods using liquid chromatography - mass spectrometry ...


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Mirror image molecules reveal drought stress in forests

Ecosystem changes can be more accurately predicted by emissions of chiral compounds


Worldwide, plants emit about 100 million tonnes of monoterpenes into the atmosphere each year. These volatile organic molecules include many fragrances such as the molecule pinene – known for its pine fresh scent. Since these molecules are highly reactive and can form tiny aerosol particles that ...


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Shining some light on the obscure proteome

Chemoproteomics draw the target landscape of HDAC drugs


Mass-spectrometry based proteomics is the big-data science of proteins that allows the monitoring of the abundance of thousands of proteins in a sample at once. Therefore, it is a particularly well-suited readout for discovering which proteins are targeted by any small molecule. An international ...


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Mass spectrometry-based draft of the mouse proteome

A milestone for biomedical research


Proteins control and organize almost every aspect of life. The totality of all proteins in a living organism, a tissue or a cell is called the proteome. Using mass spectrometry, researchers at the Technical University of Munich (TUM) characterize the proteome, or protein complement of the genome, ...


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New method revolutionizes cancer diagnosis

Ground-breaking technology ‘Deep Visual Proteomics’ unites four technologies


How does cancer arise? How does cellular composition influence tumor malignancy? These questions are profound and challenging to answer, but are crucial to understand the disease and find the right cure. Now, a German-Danish team led by Professor Matthias Mann has developed a ground-breaking ...


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analytica 2022: New instruments for personalized medicine

Mass spectrometry and the like as tools of biomarker analytics


From cancer to birth defects to infectious disease: Modern gene and bioanalysis is the key to personalized medicine. Its goal it to increase the success rate of recovery and minimize side effects by examining the illness and the individual characteristics of a patient as precisely as possible. ...


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Scientists identify cancer biomarkers in breast milk

Proteins could one day allow breast cancer screening to be done with a blood test


A simple blood test for women of all ages and risk levels could one day be possible thanks to a new set of protein biomarkers that researchers identified using breast milk. “Although mammograms are a useful tool for catching breast cancer early, they aren’t typically recommended for low-risk ...


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Glycation in the body: Trigger of protein dysfunction in aging and age-related diseases

Study powerfully demonstrates how the consequences of glycation for the whole proteome can be studied


To maintain organ functions, the proteins in the cells need to be kept in balance (proteostasis). This state is disturbed with increasing age. One possible cause is glycation, in which sugars and proteins combine irreversibly. These advanced glycation end products (AGEs) accumulate and can lead ...


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Blow flies can be used to detect use of chemical weapons, other pollutants

Using mass spectrometry to determine the chemicals in the blow flies' guts


Researchers at the School of Science at IUPUI have found that blow flies can be used as chemical sensors, with a particular focus on the detection of chemical warfare agents. Despite widespread bans, chemical weapons have been deployed in recent conflicts such as the Syrian civil war, and some ...


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