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For a Better Contrast

Rare earth orthoferrite LnFeO3 nanoparticles for bioimaging

06-Sep-2018

Magnetic resonance imaging (MRI) has emerged as one of the most powerful clinical imaging tools because of its superb spatial resolution and soft tissue contrast, especially when using contrast agents. In the European Journal of Inorganic Chemistry, scientists have presented a new kind of ...

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Smart Fluorescent Dyes

Modulating photo- and electroluminescence in a stimuli-responsive molecular dye

17-Aug-2018

Controlling the excited electronic states in luminescent systems remains a challenge in the development of fluorescent and phosphorescent dyes. Now, scientists in Japan have developed a unique organic fluorophore that changes its emission color without loss of efficiency when externally ...

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Color Change Unmasks Lead

Triplex-signal chemosensor for naked eye and spectrometric lead detection

29-May-2018

Environmental lead exposure is one of the most significant public health threats worldwide. Consequently, reliable, quick, inexpensive, and easy-to-handle lead assays are urgently needed. Scientists have now presented a novel chemosensor for lead. It offers a triplex signal upon binding of lead ...

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Direct radiolabeling of nanomaterials

10-Feb-2017

Positron emission tomography plays a pivotal role for monitoring the distribution and accumulation of radiolabeled nanomaterials in living subjects. The radioactive metals are usually connected to the nanomaterial through an anchor, a so-called chelator, but this chemical binding can be omitted ...

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Short, Ultrashort, Sub-Cycle Short

Making light pulses ever-shorter is one of the goals in ultrafast optics.

04-Jun-2015

Ultrashort light pulses are a valuable achievement. They make it possible to observe chemical reactions, opening up the field of femtochemistry. Other current and/or future applications include high capacity telecommunications systems, photonic switching devices, optical coherence tomography, and ...

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Three wavelengths will do

Practical approach for assessing the melanin and blood content of the skin

24-Apr-2015

Many factors can change skin pigmentation, including aging, exposure to UV light, certain drugs, as well as certain diseases. A simple technique for measuring skin pigmentation could be a helpful tool for research and diagnostics. The same goes for measuring the skin blood content. Alteration of ...

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Trapping and watching motile cells

A new approach enables rapid characterization of living suspension cells in 4 dimensions

01-Apr-2015

Optical imaging of highly motile cells or cells in suspension, such as bacterial systems, yeast cells, and immune cells, is a challenging task, in many cases it is just not possible. The human immunodeficiency virus (HIV), for example, can spread very efficiently from an infected T cell to an ...

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New Endoscopic Technique

Flexible wide-field endoscope provides label-free contrast of tissue based on fluorescence lifetime imaging of tissue autofluorescence

11-Feb-2015

Fluorescence lifetime imaging (FLIM) of tissue autofluorescence has been shown to provide labelfree contrast between different types and states of tissue. Clinical FLIM can combine lifetime contrast with morphological information to provide a direct comparison between different spatial regions – ...

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Measuring Skin Rejuvenescence

In vivo and non-invasive: Collagen remodeling after micro-ablative fractional laser resurfacing can be monitored by two-photon microscopy.

25-Nov-2014

Many people in the Western World consider it as a social need to hide the effects of aging. For this purpose, different cutaneous rejuvenation treatments have been developed, including a laser-based technique, known as laser resurfacing. Skin irradiation with high-power pulsed laser light induces ...

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Exploiting synergies

12-Dec-2013

Multimodal nonlinear microscopy has matured to a key imaging modalities in life science and biomedicine. It offers label-free visualization of tissue structure and chemical composition, high depth penetration, intrinsic 3D sectioning, diffraction limited resolution and low phototoxicity. In the ...

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