16 Current news of University of Pennsylvania

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Decoding Lil BUB: Crowdfunded project reveals genome of internet celebrity cat

06-Mar-2019

Lil BUB has drawn millions of followers across the internet for her cute appearance. Behind the celebrity cat’s unique features is a combination of two rare genetic variants, three molecular biologists from Germany and the US report. The results of their crowdfunded project “LilBUBome” are now ...

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Genetic variants reveal new targets for chronic kidney disease treatment

How specific cell types can lead to development of disease

04-Oct-2018

The kidney does more than double or even triple duty compared to other organs - it extracts waste, balances body fluids, forms urine, regulates blood pressure, and secretes hormones. Given this complexity, when things go wrong, havoc can ensue, causing a suite of symptoms called chronic kidney ...

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New treatment target for melanoma identified

18-Jan-2018

Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma. For decades, research has associated female sex and a history of previous pregnancy with better outcomes after a melanoma diagnosis. Now, a ...

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First DNA sequence from a single mitochondria

08-Dec-2017

DNA sequences between mitochondria within a single cell are vastly different, found researchers in the Perelman School of Medicine at the University of Pennsylvania. This knowledge will help to better illuminate the underlying mechanisms of many disorders that start with accumulated mutations in ...

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How to control liquid crystal patterns

03-Nov-2017

When Lisa Tran set out to investigate patterns in liquid crystals, she didn't know what to expect. When she first looked through the microscope, she saw dancing iridescent spheres with fingerprint-like patterns etched into them that spiraled and flattened as the solution they were floated in ...

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How does a cell maintain its identity during replication?

18-Sep-2017

Prior to cell division, chromosomes are seemingly a jumbled mess. During cell division, parent cell chromosomes and their duplicates sort themselves out by condensing, becoming thousands of times more compact than at any other time. Researchers have long assumed that genes become "silent" during ...

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New biomarker found for group of rare metabolic diseases

09-Aug-2017

A newly discovered biomarker associated with a rare metabolic disorder may facilitate better diagnosis and identification of new drugs for clinical trials for the disease, according to researchers in the Perelman School of Medicine at the University of Pennsylvania. Development of treatments for ...

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Research on crucial cutting enzyme maps sites of DNA damage in leukemias and other cancers

16-Jun-2017

Researchers studying a DNA-cutting enzyme with a crucial role in regulating the structure of genes have discovered a broad role for its cutting activity in driving abnormal genetic rearrangements called translocations that cause cancer, including leukemias and solid tumors. The enzyme, type II ...

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'Mysterious' non-protein-coding RNAs play important roles in gene expression

16-Jan-2017

In cells, DNA is transcribed into RNAs that provide the molecular recipe for cells to make proteins. Most of the genome is transcribed into RNA, but only a small proportion of RNAs are actually from the protein-coding regions of the genome. "Why are the non-coding regions transcribed at all? ...

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Brain reward molecule helps learning to avoid unpleasant experience

02-Mar-2016

The brain chemical dopamine regulates how mice learn to avoid a disagreeable encounter, according to new research from the Perelman School of Medicine at the University of Pennsylvania. "We know that dopamine reinforces 'rewarding' behaviors, but to our surprise, we have now shown that situations ...

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