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Optimal concentrations of enzymes and their substrates

Until now, scientists assumed that no general relationship exists between the individual concentrations

01-Nov-2021

Biological cells invest much of their resources into the production of enzymes, which catalyze the conversion of substrates into products. An international team of bioinformaticians and biophysicists, led by Prof. Martin Lercher from Heinrich Heine University Düsseldorf (HHU), discovered that ...

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AI helping to quantify enzyme activity

22-Oct-2021

Without enzymes, an organism would not be able to survive. It is these biocatalysts that facilitate a whole range of chemical reactions, producing the building blocks of the cells. Enzymes are also used widely in biotechnology and in our households, where they are used in detergents, for ...

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Tiny sensors for major advances

Using NMR spectrometry to analyse important molecules that have not been accessible before now

18-May-2021

An international research team involving the working group of biophysicist Dr. Manuel Etzkorn from Heinrich Heine University Düsseldorf (HHU) has developed an approach for using NMR spectrometry to analyse important molecules that have not been accessible before now. In the journal Angewandte ...

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64 human genomes as new reference for global genetic diversity

The new reference data provide an important basis: The aim is to estimate the individual risk of developing certain diseases such as cancer

04-Mar-2021

Exactly 20 years after the successful completion of the "Human Genome Project", an international group of researchers, the Human Genome Structural Variation Consortium (HGSVC), has now sequenced 64 human genomes at high resolution. This reference data includes individuals from around the world, ...

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Unlocking the secrets of plant genomes in high resolution

New software tool allows for precise assignment to the correct copies – a process known as ‘phasing’

23-Sep-2020

Resolving genomes, particularly plant genomes, is a very complex and error-prone task. This is because there are several copies of all of the chromosomes and they are very alike. A team of bioinformatics researchers from Heinrich Heine University Düsseldorf (HHU) has now developed a software tool ...

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Genetic key to "healthy" tea

Genome of an ancient tea tree elucidated and more than 200 different tea varieties analysed

03-Aug-2020

Tea (Camellia sinensis) is one of the world's most popular drinks with a wide range of flavours and health benefits. Researchers from Huazhong Agricultural University of Wuhan (China), Forschungszentrum Jülich, Heinrich Heine University Düsseldorf and the Max Planck Institute of Molecular Plant ...

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Superresolution live-cell imaging provides unexpected insights into the dynamic structure of mitochondria

20-Feb-2020

As power plants and energy stores, mitochondria are essential components of almost all cells in plants, fungi and animals. Until now, it has been assumed that these functions underlie a static structure of mitochondrial membranes. Researchers at the Heinrich Heine University Düsseldorf (HHU) and ...

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Assemblies of proteins relevant not only for Alzheimer’s and Parkinson’s disease

23-Aug-2019

Amyloid fibrils play a crucial role in neurodegenerative illnesses. Scientists from Heinrich Heine University Düsseldorf (HHU) and Forschungszentrum Jülich have now been able to use cryo-electron microscopy (cryo-EM) to decode the spatial structure of the fibrils that are formed from PI3K SH3 ...

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Alzheimer’s Disease: New Test Identifies the Most Promising Drug Candidates

16-Oct-2015

Despite enormous efforts of scientists around the world, an effective and causal treatment against Alzheimer’s disease is yet to be found. Many substances that seemed promising initially, later failed in clinical trials, proving ineffective only after years of costly and time consuming tests. ...

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Brain mages of previously unattainable quality

25-Jun-2013

A new three-dimensional model of the brain now provides in-depth insights into the human control centre. It allows us to see and understand the complicated structure of the brain on a microscopic level in all three spatial dimensions for the first time. This is made possible using images with a ...

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