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How Poxviruses Multiply

For the first time, the polymerase of vaccinia viruses observed at work at the atomic level

27-Sep-2021

Poxviruses have found a unique way of translating their genes into proteins in the infected organism. For the first time, scientists of the University of Würzburg's Biocenter have been able to gain atomic-level insights into the functioning of the molecular machinery involved in the process. The ...

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Obstacles on the racetrack of life

New picture of the transcription

19-Jul-2021

mRNA plays a key role in the conversion of genetic information from DNA to proteins. Their production is a delicate process. A research team at the University of Würzburg has now identified a crucial factor. The corona pandemic has ensured that the term "mRNA" is now also known to a large public ...

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Team tracks real-time molecular motions

Important new insights into a key process for the development of more efficient solar cells

09-Jul-2021

The efficiency of solar cells can be significantly increased with a certain physical effect. A research team has now observed in detail for the first time how molecular movements influence this effect. Researchers from the Fritz Haber Institute (FHI) in Berlin, the Max Planck Institute for the ...

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Diagnoses with Deepflash

Microscopic images of tissue sections can now be analyzed much more easily

11-Jun-2021

Information technology can make life easier in many areas – including research. In medicine, for example, it is still standard practice to evaluate microscopy images of tissue sections by hand. This is used, for example, to assess how many cancer cells are in a lymph node. "You often sit in a ...

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CRISPR discovery paves the way for novel COVID testing method

LEOPARD has the potential to revolutionize diagnostics

29-Apr-2021

Am I infected with SARS-CoV-2? Is it one of the dangerous variants? Being able to answer these and more questions with a single efficient diagnostic test can be decisive for gauging the spread of disease and selecting the right therapy. In a study published in the journal "Science", researchers ...

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First 3D Images of a Giant Molecule

Resolution up to a millionth of a millimeter

26-Mar-2021

Capturing the structure of large molecular complexes with variable shape is an extremely difficult task. Scientists from Würzburg and Montpellier now have been able to do it – thanks to a new approach regarding an important protein machine. SMN or in full Survival Motor Neuron: Professor Utz ...

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Cell Membranes in Super Resolution

For the first time ever, expansion microscopy allows the imaging of even the finest details of cell membranes. This offers new insights into bacterial and viral infection processes

04-Dec-2020

Expansion microscopy (ExM) enables the imaging of cells and their components with a spatial resolution far below 200 nanometres. For this purpose, the proteins of the sample under investigation are cross-linked into a swellable polymer. Once the interactions between the molecules have been ...

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Hurdle of microscopy overcome

Smallest cell structures can now be imaged even better

10-Jul-2020

High-resolution microscopy makes it theoretically possible to image cell structures with a resolution of a few nanometres. However, this has not yet been possible in practice. The reason for this is that antibodies carrying a fluorescent dye are usually used to mark the cell structures. The dye ...

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High-end Microscopy Refined

New details are known about an important cell structure

06-Jul-2020

For the first time, two Würzburg research groups have been able to map the synaptonemal complex three-dimensionally with a resolution of 20 to 30 nanometres. The synaptonemal complex is a ladder-like cell structure that plays a major role in the development of egg and sperm cells in humans and ...

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Herpes virus decoded using new methods

A comprehensive systems biological analysis of the herpes virus genome has caused some surprises

30-Apr-2020

The genome of the herpes simplex virus 1 was decoded using new methods. Hundreds of previously unknown gene products were found. The virus causes lip herpes, but can also be life-threatening. Until now, scientists had assumed that there are about 80 so-called open reading frames (ORFs) in the ...

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