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Cell Membranes in Super Resolution

For the first time ever, expansion microscopy allows the imaging of even the finest details of cell membranes. This offers new insights into bacterial and viral infection processes

04-Dec-2020

Expansion microscopy (ExM) enables the imaging of cells and their components with a spatial resolution far below 200 nanometres. For this purpose, the proteins of the sample under investigation are cross-linked into a swellable polymer. Once the interactions between the molecules have been ...

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Hurdle of microscopy overcome

Smallest cell structures can now be imaged even better

10-Jul-2020

High-resolution microscopy makes it theoretically possible to image cell structures with a resolution of a few nanometres. However, this has not yet been possible in practice. The reason for this is that antibodies carrying a fluorescent dye are usually used to mark the cell structures. The dye ...

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High-end Microscopy Refined

New details are known about an important cell structure

06-Jul-2020

For the first time, two Würzburg research groups have been able to map the synaptonemal complex three-dimensionally with a resolution of 20 to 30 nanometres. The synaptonemal complex is a ladder-like cell structure that plays a major role in the development of egg and sperm cells in humans and ...

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Herpes virus decoded using new methods

A comprehensive systems biological analysis of the herpes virus genome has caused some surprises

30-Apr-2020

The genome of the herpes simplex virus 1 was decoded using new methods. Hundreds of previously unknown gene products were found. The virus causes lip herpes, but can also be life-threatening. Until now, scientists had assumed that there are about 80 so-called open reading frames (ORFs) in the ...

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Virus multiplication in 3D

16-Dec-2019

Vaccinia viruses serve as a vaccine against human smallpox and as the basis of new cancer therapies. Two studies now provide fascinating insights into their unusual propagation strategy at the atomic level. For viruses to multiply, they usually need the support of the cells they infect. In many ...

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Tuberculosis: New insights into the pathogen

11-Oct-2019

Researchers at the University of Würzburg and the Spanish Cancer Research Centre have gained new insights into the pathogen that causes tuberculosis. The work published in Nature provides the basis for a new approach in antibiotic therapy. Tuberculosis is a highly contagious infectious disease ...

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New findings about anti-malaria drug

30-Jan-2019

Artemisinin is derived from the leaves and flowers of the annual mugwort (Artemisia annua) and has been used in traditional Chinese medicine for centuries. The effectiveness was investigated by the Chinese researcher Tu Youyou. Her research was 2015 rewarded with the Nobel Prize. Artemisinin and ...

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Progress in Super-Resolution Microscopy

20-Dec-2018

Does expansion microscopy deliver true-to-life images of cellular structures? That was not sure yet. A new publication shows for the first time that the method actually works reliably. Immersing deeper and deeper into cells with the microscope. Imaging the nucleus and other structures more and ...

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Stagediving with biomolecules improves optical microscopy

03-May-2018

Physicists from Dresden and Würzburg have developed a novel method for optical microscopy. Using biological motors and single quantum dots, they acquire ultra-high-resolution images. The resolution of conventional optical microscopy is limited by the fundamental physical principle of diffraction ...

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Individual Receptors Caught at Work

Technological developments allow new insights

23-Oct-2017

Using a revolutionary live-cell microscopy technique, an international team of scientist has observed for the first time individual receptors for hormones and widely used drugs at work in intact cells. G protein-coupled receptors (GPCRs) are among the "hottest” targets for the therapy of diseases ...

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