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Most complex protein knots

Theoretical physicists put Google's artificial intelligence AlphaFold to the test and find the most complex protein knots so far

20-Jul-2022

The question of how the chemical composition of a protein, the amino acid sequence, determines its 3D structure has been one of the biggest challenges in biophysics for more than half a century. This knowledge about the so-called "folding" of proteins is in great demand, as it contributes ...

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3D imaging study reveals how atoms are packed in amorphous materials

UCLA-led research could revise a 70-year-old model of how the fundamental building blocks of substances are assembled

20-Oct-2021

Many substances around us, from table salt and sugar to most metals, are arranged into crystals. Because their molecules are laid out in an orderly, repetitive pattern, much is understood about their structure. However, a far greater number of substances — including rubber, glass and most liquids ...

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Deep learning enables early detection and classification of live bacteria using holography

Development of an AI-powered smart imaging system for early-detection and classification of live bacteria in water samples

15-Jul-2020

Waterborne diseases affect more than 2 billion people worldwide, causing substantial economic burden. For example, the treatment of waterborne diseases costs more than $2 billion annually in the United States alone, with 90 million cases recorded per year. Among waterborne pathogen-related ...

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Superresolution live-cell imaging provides unexpected insights into the dynamic structure of mitochondria

20-Feb-2020

As power plants and energy stores, mitochondria are essential components of almost all cells in plants, fungi and animals. Until now, it has been assumed that these functions underlie a static structure of mitochondrial membranes. Researchers at the Heinrich Heine University Düsseldorf (HHU) and ...

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'Scaffolding' method allows biochemists to see proteins in remarkable detail

16-Apr-2018

UCLA biochemists have achieved a first in biology: viewing at near-atomic detail the smallest protein ever seen by the technique whose development won its creators the 2017 Nobel Prize in chemistry. That technique, called cryo-electron microscopy, enables scientists to see large biomolecules, ...

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Stingray soft robot could lead to bio-inspired robotics

16-Jan-2018

UCLA bioengineering professor Ali Khademhosseini has led the development of a tissue-based soft robot that mimics the biomechanics of a stingray. The new technology could lead to advances in bio-inspired robotics, regenerative medicine and medical diagnostics. The simple body design of stingrays, ...

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How to amplify or stifle signals for immune responses

09-Mar-2017

T cells, the managers of our immune systems, spend their days shaking hands with another type of cell that presents small pieces of protein from pathogens or cancerous cells to the T cell. But each T cell is programmed to recognize just a few protein pieces, known as antigens, meaning years can ...

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Combatting antimicrobial resistance with smartphones

A simple and inexpensive attachment could help to expand testing to regions with limited resources.

16-Dec-2016

A team of UCLA researchers has developed an automated diagnostic test reader for antimicrobial resistance using a smartphone. The technology could lead to routine testing for antimicrobial susceptibility in areas with limited resources. Antimicrobial-resistant bacteria are posing a severe threat ...

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Physicists demonstrate method to study atoms critical to medicine

13-Oct-2016

UCLA physicists have shown that shining multicolored laser light on rubidium atoms causes them to lose energy and cool to nearly absolute zero. This result suggests that atoms fundamental to chemistry, such as hydrogen and carbon, could also be cooled using similar lasers, an outcome that would ...

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Physicists determine 3-D positions of individual atoms for the first time

23-Sep-2015

Atoms are the building blocks of all matter on Earth, and the patterns in which they are arranged dictate how strong, conductive or flexible a material will be. Now, scientists at UCLA have used a powerful microscope to image the three-dimensional positions of individual atoms several times ...

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