Resistance to the anti-cancer medication cetuximab

Insights into mechanisms

26-Sep-2018 - Okayama University researchers report that the anti-cancer drug cetuximab is released with vesicles from cancer cells, findings that may enable the development of strategies to improve the effectiveness of cetuximab for treating head and neck cancer. Head and neck squamous cell carcinoma (HNSCC) ...

Potential origin of cancer-associated cells revealed

12-Sep-2017 - Researchers at Okayama University describe that cancer-associated fibroblasts — cells that play a key role in cancer progression — originate from cancer stem cells. Preventing cancer stem cells from transforming into cancer-associated fibroblast may be a promising approach towards cancer ...

Aeroices: Newly discovered ultralow-density ice

07-Sep-2017 - Water has many ice phases that form under different pressure and temperature conditions. The effects of positive pressure have been explored extensively, with the results somewhat predictable: As the pressure increases, so does the density of the ice. Much less is known, however, about the ...

Overloading of protein localization triggers cellular defects

07-Mar-2017 - Researchers at Okayama University report how the overloading of protein transport mechanisms affects cell functioning. Over-expression of different types of target proteins leads to cellular growth defects, and the mechanism for transporting proteins out of a cell nucleus has the lowest ...

A new future for an old crop: barley enters the genomics age

30-Jan-2013 - The barley genome is almost twice the size of that of humans and determining the sequence of its DNA has proved to be a major challenge. This paper published in Nature is a detailed overview of the functional portions of the barley genome, revealing the order and structure of its 26,000 genes. ...