7 Current news of MPI für molekulare Genetik
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Hunting for disease clues in the dark matter of our DNA
20-Jan-2023
Scientists have reconstructed the chromosomes of patients with an extremely high number of aberrations in their genome that could alter the expression of nearby genes and potentially cause disease. Their results were published in Nature Communications in October 2022. “We are only beginning to ...
New method facilitates identification of cell-type specific genes in single-cell data
06-Jul-2022
The thousands of cells in a biological sample are all different and can be analyzed individually, cell by cell. Based on their gene activity, they can be sorted into clusters. But which genes are particularly characteristic of a given cluster, i.e. what are its “marker genes”? A new statistical ...
165 new cancer genes identified with the help of machine learning
19-Apr-2021
A new algorithm can predict which genes cause cancer, even if their DNA sequence is not changed. A team of researchers in Berlin combined a wide variety of data, analyzed it with “Artificial Intelligence” and identified numerous cancer genes. This opens up new perspectives for targeted cancer ...
New method to improve the diagnosis of genetic diseases
28-Jul-2020
Breaks and rearrangements in the genome can lead to severe diseases, even if all genes remain intact. Hi-C, a method to map the three-dimensional structure of chromosomes, promises more reliable and accurate diagnoses of such defects, but is not used in the clinic yet. A team of researchers at ...
Multifunctional tool CRUP makes enhancer prediction quick and easy
21-Nov-2019
It is the the dream of every molecular geneticist: an easy-to-use program that compares data sets from different cellular conditions, identifies enhancer regions and then assigns them to their target genes. A research team led by Professor Martin Vingron at the Max Planck Institute for Molecular ...
06-Mar-2019
Lil BUB has drawn millions of followers across the internet for her cute appearance. Behind the celebrity cat’s unique features is a combination of two rare genetic variants, three molecular biologists from Germany and the US report. The results of their crowdfunded project “LilBUBome” are now ...
PhenIX can identify genetic diseases quickly and reliably based on analyses of genes and symptoms
19-Sep-2014
People with genetic diseases often have to embark on an odyssey from one doctor to the next. Fewer than half of all patients who are suspected of having a genetic disease actually receive a satisfactory diagnosis. Scientists from the Charité - Universitätsmedizin Berlin and the Max Planck ...
