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5 Current news of MPI für molekulare Biomedizin

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Hammock for brain organoids

Novel microelectrode array system enables long-term cultivation and electrophysiological analyses

14-Apr-2023 - Brain organoids are self-organizing tissue cultures grown from patient cell-derived induced pluripotent stem cells. They form tissue structures that resemble the brain in vivo in many ways. This makes brain organoids interesting for studying both normal brain development and for the development ...

brain organoids
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More than microscopes can show

Computer simulations visualize how an essential stem cell protein opens wrapped DNA

23-Sep-2022 - A key protein for converting adult stem cells into cells that resemble embryonic stem cells has been visualized in unprecedented detail by an international team of researchers around Hans Schöler and Vlad Cojocaru of the Max Planck Institute for Molecular Biomedicine in Münster. By combing ...

computer simulations histones nanoscopy +2
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Nucleosome breathing from atomistic time snapshots

Computer simulations visualize in atomic detail how DNA opens while wrapped around proteins

08-Jun-2021 - Researchers from the Hubrecht Institute in Utrecht (The Netherlands) and the Max Planck Institute for Molecular Biomedicine in Münster (Germany) used computer simulations to reveal in atomic detail how a short piece of DNA opens while it is tightly wrapped around the proteins that package our ...

chromatin DNA nucleosomes
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Midbrain organoids for automated chemical screening and disease research

Max Planck Innovation licenses process for the generation of organ-like tissue aggregates to biotech company StemoniX

05-Nov-2020 - Sometimes hundreds of thousands of potential therapeutics need to be tested in large-scale, fully automated experiments to identify a single effective drug. Most compounds do not work as desired, and some are even toxic. Since the development of the induced Pluripotent Stem (iPS) Cell technology ...

drug development drug discovery induced pluripotent stem cells +1
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New tool helps to ‘spot the difference’ in genome organisation

This enables scientists to track down causes of diseases more quickly

22-Oct-2020 - The way DNA is organized in the cell nucleus is very important for the normal development and function of the cell. A mutation that affects the packaging of the genetic material in the cell nucleus can lead to developmental disorders or diseases such as cancer. A team of scientists from the Max ...

cancer cell nucleus chromosomes +4