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New method for early diagnosis of liver diseases by proteomics

A research team has developed a new screening method to identify alcohol-related liver diseases at an early stage through mass spectromy based proteomics

06-Jun-2022

Two or three drinks every day could put your liver in danger. Using proteomics and machine learning, researchers now present a revolutionary tool to predict whether an individual has alcohol-related liver disease and if an individual patient is at risk of disease progression. In comparison to the ...

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New method revolutionizes cancer diagnosis

Ground-breaking technology ‘Deep Visual Proteomics’ unites four technologies

23-May-2022

How does cancer arise? How does cellular composition influence tumor malignancy? These questions are profound and challenging to answer, but are crucial to understand the disease and find the right cure. Now, a German-Danish team led by Professor Matthias Mann has developed a ground-breaking ...

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Molecular scales on biological membranes: Mass-Sensitive Particle Tracking

New method to determine location and size changes of unlabeled proteins on membranes via their mass

06-Oct-2021

A large proportion of biologically relevant processes take place at membranes. Studying the dynamics of these processes in real time and without disturbing the biological system is still a major methodological challenge. A team led by Petra Schwille, director at the MPI of Biochemistry (MPIB), ...

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MaxDIA – taking proteomics to the next level

Highly sensitive and accurate data analysis: New software improves data-independent acquisition proteomics

12-Jul-2021

Proteomics produces enormous amounts of data, which can be very complex to analyze and interpret. The free software platform MaxQuant has proven to be invaluable for data analysis of shotgun proteomics over the past decade. Now, Jürgen Cox, group leader at the Max Planck Institute of ...

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A multidimensional view of the coronavirus

Covid-19: analysis of protein interactions as a route to new drugs

20-Apr-2021

What exactly happens when the corona virus SARS-CoV-2 infects a cell? In an article published in Nature, a team from the Technical University of Munich (TUM) and the Max Planck Institute of Biochemistry paints a comprehensive picture of the viral infection process. For the first time, the ...

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The relationship of proteins

Researchers have for the first time uncovered the proteome of 100 organisms from all domains of life

19-Jun-2020

Proteins control life as one of the most important biomolecules - as enzymes, receptors, signal or structural building blocks. Researchers at the Max Planck Institute (MPI) of Biochemistry have for the first time uncovered the proteomes of 100 different organisms. The selected specimens come from ...

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The recipe for making a fruit fly

Scientists use mass spectrometry to determine the absolute copy number of nuclear proteins and histone marks

21-Oct-2019

Currently, most if not all of the proteins that are required for constructing a multicellular organism are known. However, it is largely unclear how many copies of each protein species are present and needed to permit an animal to develop into a complete organism. Researchers at the Max Planck ...

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Screening proteins to expose early signs of illness

Matthias Mann named European Inventor Award 2019 finalist

08-May-2019

The European Patent Office (EPO) announces that German physicist, biochemist and bioinformatician Matthias Mann has been nominated for the European Inventor Award 2019 for developing techniques to screen proteins in bulk for the early detection of disease. Named as one of three finalists in the ...

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Molecular Force Sensors

21-Sep-2017

Proteins are often considered as molecular machines. To understand how they work, it is not enough to visualize the involved proteins under the microscope. Wherever machines are at work mechanical forces occur, which in turn influence biological processes. These extremely small intracellular ...

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The battery compartments of the 26S Protein Recycling Machine

29-Jun-2016

The degradation of proteins and the re-use of their basic building blocks is a process that is a matter of survival in cells. Researchers at the Max-Planck-Institute for Biochemistry present a detailed structure of the human protein recycling machine, the so-called 26S proteasome, in near-atomic ...

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