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Innovative Blood Test Based on Infrared Light

Monitoring health and detect disorders at an early stage

11-Mar-2021

A new study carried out by a team of laser physicists, molecular biologists and physicians based at LMU Munich and the Max Planck Institute for Quantum Optics has confirmed the temporal stability of the molecular composition of blood in a population of healthy individuals. The data provide a ...

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Detecting single molecules and diagnosing diseases with a smartphone

Researchers show that the light emitted by a single molecule can be detected with a low-cost optical setup. Their prototype could facilitate medical diagnostics

17-Feb-2021

Biomarkers play a central role in the diagnosis of disease and assessment of its course. Among the markers now in use are genes, proteins, hormones, lipids and other classes of molecules. Biomarkers can be found in the blood, in cerebrospinal fluid, urine and various types of tissues, but most of ...

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Fluorescence microscopy at highest spatial and temporal resolution

Researchers simplify the MINFLUX microscope and have succeeded in differentiating molecules that are extremely close together and tracking their dynamics.

21-Jan-2021

Only a few years ago, an ostensibly fundamental resolution limit in optical microscopy was superseded - a breakthrough which in 2014 led to the Nobel Prize in Chemistry for super-resolution microscopy. Since then, there has been another quantum leap in this area, which has further reduced the ...

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Shining a light on nanoscale dynamics

Watching metamaterials at work in real time using ultrafast electron diffraction

26-Nov-2020

Physicists from the University of Konstanz, Ludwig-Maximilians-Universität München (LMU Munich) and the University of Regensburg have successfully demonstrated that ultrashort electron pulses experience a quantum mechanical phase shift through their interaction with light waves in nanophotonic ...

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Gene editing: Taming CRISPR’s collateral damage

Simple method to detect unintended alterations in the target gene itself – results indicate that such on-target events occur at high frequency

28-May-2020

CRISPR-Cas9 can alter genes at pre-defined sites in specific ways, but it does not always act as planned. An LMU team has now developed a simple method to detect unintended ‘on-target’ events, and shown that they often occur in human stem cells. The gene-editing system CRISPR-Cas9 has ...

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Lifting the lid on beta-barrels

02-Apr-2020

The interaction between biotin and streptavidin is a well-established experimental tool in bionanotechnology. LMU physicists have now shown that the mechanical stability of the complex is dependent on the precise geometry of the interface. Mechanical forces play a vital role at all levels in ...

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Tonsils as a testbed

02-Mar-2020

Biomedical researchers at LMU have isolated immune cells from human tonsils obtained following routine surgery, and used them to analyze aspects of the immune response and test the effects of anti-inflammatory agents at the cellular level. Human tissues that have been surgically removed from ...

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Gene scissors against incurable muscular disease

New gene correction therapy

30-Jan-2020

Duchenne type muscular dystrophy (DMD) is the most common hereditary muscular disease among children. A Munich based team has developed a gene therapy that may provide permanent relief for those suffering from DMD. LMU researcher Eckhard Wolf was involved in the study. Muscles need dystrophin in ...

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All in a flash! Eliminate proteins from cells with a flash of light

24-Jan-2020

LMU scientists have developed a tool to eliminate essential proteins from cells with a flash of light. The new method makes it possible to study the function of essential proteins. Proteins not only provide much of the structural architecture of cells, they also perform most of the executive ...

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A fine sense for molecules

Unique laser technology for the analysis of the molecular composition of biological samples

07-Jan-2020

At the biochemical level, organisms can be thought of as complex collections of different species of molecules. In the course of their metabolism, biological cells synthesize chemical compounds, and modify them in multifarious ways. Many of these products are released into the intercellular ...

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