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Most powerful dual-comb spectrometer developed

System paves the way for many applications

30-May-2022

Scientists from Hamburg and Munich developed the world's most powerful dual-comb spectrometer that paves the way for many applications in atmospheric science and biomedical diagnostics, such as early cancer detection. The work has recently been published in Nature Communications. The core part of ...

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Finding the invisible

Researchers have developed a method to extract more information from sequencing data

12-Jan-2022

Higher organisms store their genetic material in the nuclei of cells as deoxyribonucleic acid (DNA). In a process called transcription, individual segments, the genes, are converted into messenger ribonucleic acids (mRNAs). Subsequently, the translation process produces proteins as the most ...

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HIV infection: Better understanding the reservoir of virus in the body

Researchers have developed a method that allows resting human immune cells to be genetically analyzed in detail for the first time.

04-Jan-2022

CD4+ T cells are important parts of the immune system and play a key role in defending the body against pathogens. As they possess a great variety of defense mechanisms against HIV in their resting state, they are infected only very rarely – but these few infected cells form a latent reservoir ...

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PCR: Activated by light

New approach could help to significantly improve diagnostic tests based on PCR

20-Dec-2021

DNA polymerases and other enzymes that modify DNA are essential tools in biotechnology and diagnostics. They are the key component for COVID-19 diagnostics by PCR. As useful as they are, DNA processing enzymes often have important flaws. Some of them display significant activity during the ...

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Previously unknown mode of bacterial growth discovered

Research teams use imaging and modelling to explain why single bacterial cells do not always grow exponentially

18-Nov-2021

Bacteria as unicellular organisms reproduce by dividing their entire organism. In this way, they can multiply particularly quickly, which allows the exponential growth of bacterial populations, also known from pathogens. The population growth is based on the growth of the individual bacterial ...

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Point-of-care diagnostics: New methods for detecting single molecules

Pathogen-specific detection: Even one single DNA molecule is enough

04-Nov-2021

Resistance to antibiotics is on the rise worldwide. Researchers at the Fraunhofer Institute for Physical Measurement Techniques IPM alongside the Ludwig Maximilian University of Munich have developed a process for rapidly detecting multidrug-resistant pathogens. The unique feature: Even one ...

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In neurodegenerative diseases, brain immune cells have a “ravenous appetite” for sugar

The interpretation of certain brain scans needs rethinking

15-Oct-2021

At the beginning of neurodegenerative disease, the immune cells of the brain – the “microglia” – take up glucose, a sugar molecule, to a much greater extent than hitherto assumed. Studies by the DZNE, the LMU München and the LMU Klinikum München, published in the journal Science Translational ...

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Molecular scales on biological membranes: Mass-Sensitive Particle Tracking

New method to determine location and size changes of unlabeled proteins on membranes via their mass

06-Oct-2021

A large proportion of biologically relevant processes take place at membranes. Studying the dynamics of these processes in real time and without disturbing the biological system is still a major methodological challenge. A team led by Petra Schwille, director at the MPI of Biochemistry (MPIB), ...

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Innovative Blood Test Based on Infrared Light

Monitoring health and detect disorders at an early stage

11-Mar-2021

A new study carried out by a team of laser physicists, molecular biologists and physicians based at LMU Munich and the Max Planck Institute for Quantum Optics has confirmed the temporal stability of the molecular composition of blood in a population of healthy individuals. The data provide a ...

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Detecting single molecules and diagnosing diseases with a smartphone

Researchers show that the light emitted by a single molecule can be detected with a low-cost optical setup. Their prototype could facilitate medical diagnostics

17-Feb-2021

Biomarkers play a central role in the diagnosis of disease and assessment of its course. Among the markers now in use are genes, proteins, hormones, lipids and other classes of molecules. Biomarkers can be found in the blood, in cerebrospinal fluid, urine and various types of tissues, but most of ...

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