50 Current news of LMU

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In neurodegenerative diseases, brain immune cells have a “ravenous appetite” for sugar

The interpretation of certain brain scans needs rethinking

15-Oct-2021

At the beginning of neurodegenerative disease, the immune cells of the brain – the “microglia” – take up glucose, a sugar molecule, to a much greater extent than hitherto assumed. Studies by the DZNE, the LMU München and the LMU Klinikum München, published in the journal Science Translational ...

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Molecular scales on biological membranes: Mass-Sensitive Particle Tracking

New method to determine location and size changes of unlabeled proteins on membranes via their mass

06-Oct-2021

A large proportion of biologically relevant processes take place at membranes. Studying the dynamics of these processes in real time and without disturbing the biological system is still a major methodological challenge. A team led by Petra Schwille, director at the MPI of Biochemistry (MPIB), ...

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Innovative Blood Test Based on Infrared Light

Monitoring health and detect disorders at an early stage

11-Mar-2021

A new study carried out by a team of laser physicists, molecular biologists and physicians based at LMU Munich and the Max Planck Institute for Quantum Optics has confirmed the temporal stability of the molecular composition of blood in a population of healthy individuals. The data provide a ...

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Detecting single molecules and diagnosing diseases with a smartphone

Researchers show that the light emitted by a single molecule can be detected with a low-cost optical setup. Their prototype could facilitate medical diagnostics

17-Feb-2021

Biomarkers play a central role in the diagnosis of disease and assessment of its course. Among the markers now in use are genes, proteins, hormones, lipids and other classes of molecules. Biomarkers can be found in the blood, in cerebrospinal fluid, urine and various types of tissues, but most of ...

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Fluorescence microscopy at highest spatial and temporal resolution

Researchers simplify the MINFLUX microscope and have succeeded in differentiating molecules that are extremely close together and tracking their dynamics.

21-Jan-2021

Only a few years ago, an ostensibly fundamental resolution limit in optical microscopy was superseded - a breakthrough which in 2014 led to the Nobel Prize in Chemistry for super-resolution microscopy. Since then, there has been another quantum leap in this area, which has further reduced the ...

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Shining a light on nanoscale dynamics

Watching metamaterials at work in real time using ultrafast electron diffraction

26-Nov-2020

Physicists from the University of Konstanz, Ludwig-Maximilians-Universität München (LMU Munich) and the University of Regensburg have successfully demonstrated that ultrashort electron pulses experience a quantum mechanical phase shift through their interaction with light waves in nanophotonic ...

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Gene editing: Taming CRISPR’s collateral damage

Simple method to detect unintended alterations in the target gene itself – results indicate that such on-target events occur at high frequency

28-May-2020

CRISPR-Cas9 can alter genes at pre-defined sites in specific ways, but it does not always act as planned. An LMU team has now developed a simple method to detect unintended ‘on-target’ events, and shown that they often occur in human stem cells. The gene-editing system CRISPR-Cas9 has ...

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Lifting the lid on beta-barrels

02-Apr-2020

The interaction between biotin and streptavidin is a well-established experimental tool in bionanotechnology. LMU physicists have now shown that the mechanical stability of the complex is dependent on the precise geometry of the interface. Mechanical forces play a vital role at all levels in ...

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Tonsils as a testbed

02-Mar-2020

Biomedical researchers at LMU have isolated immune cells from human tonsils obtained following routine surgery, and used them to analyze aspects of the immune response and test the effects of anti-inflammatory agents at the cellular level. Human tissues that have been surgically removed from ...

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Gene scissors against incurable muscular disease

New gene correction therapy

30-Jan-2020

Duchenne type muscular dystrophy (DMD) is the most common hereditary muscular disease among children. A Munich based team has developed a gene therapy that may provide permanent relief for those suffering from DMD. LMU researcher Eckhard Wolf was involved in the study. Muscles need dystrophin in ...

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