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System paves the way for many applications
30-May-2022
Scientists from Hamburg and Munich developed the world's most powerful dual-comb spectrometer that paves the way for many applications in atmospheric science and biomedical diagnostics, such as early cancer detection. The work has recently been published in Nature Communications. The core part of ...
Researchers have developed a method to extract more information from sequencing data
12-Jan-2022
Higher organisms store their genetic material in the nuclei of cells as deoxyribonucleic acid (DNA). In a process called transcription, individual segments, the genes, are converted into messenger ribonucleic acids (mRNAs). Subsequently, the translation process produces proteins as the most ...
Researchers have developed a method that allows resting human immune cells to be genetically analyzed in detail for the first time.
04-Jan-2022
CD4+ T cells are important parts of the immune system and play a key role in defending the body against pathogens. As they possess a great variety of defense mechanisms against HIV in their resting state, they are infected only very rarely – but these few infected cells form a latent reservoir ...
New approach could help to significantly improve diagnostic tests based on PCR
20-Dec-2021
DNA polymerases and other enzymes that modify DNA are essential tools in biotechnology and diagnostics. They are the key component for COVID-19 diagnostics by PCR. As useful as they are, DNA processing enzymes often have important flaws. Some of them display significant activity during the ...
Research teams use imaging and modelling to explain why single bacterial cells do not always grow exponentially
18-Nov-2021
Bacteria as unicellular organisms reproduce by dividing their entire organism. In this way, they can multiply particularly quickly, which allows the exponential growth of bacterial populations, also known from pathogens. The population growth is based on the growth of the individual bacterial ...
Pathogen-specific detection: Even one single DNA molecule is enough
04-Nov-2021
Resistance to antibiotics is on the rise worldwide. Researchers at the Fraunhofer Institute for Physical Measurement Techniques IPM alongside the Ludwig Maximilian University of Munich have developed a process for rapidly detecting multidrug-resistant pathogens. The unique feature: Even one ...
The interpretation of certain brain scans needs rethinking
15-Oct-2021
At the beginning of neurodegenerative disease, the immune cells of the brain – the “microglia” – take up glucose, a sugar molecule, to a much greater extent than hitherto assumed. Studies by the DZNE, the LMU München and the LMU Klinikum München, published in the journal Science Translational ...
New method to determine location and size changes of unlabeled proteins on membranes via their mass
06-Oct-2021
A large proportion of biologically relevant processes take place at membranes. Studying the dynamics of these processes in real time and without disturbing the biological system is still a major methodological challenge. A team led by Petra Schwille, director at the MPI of Biochemistry (MPIB), ...
Monitoring health and detect disorders at an early stage
11-Mar-2021
A new study carried out by a team of laser physicists, molecular biologists and physicians based at LMU Munich and the Max Planck Institute for Quantum Optics has confirmed the temporal stability of the molecular composition of blood in a population of healthy individuals. The data provide a ...
Researchers show that the light emitted by a single molecule can be detected with a low-cost optical setup. Their prototype could facilitate medical diagnostics
17-Feb-2021
Biomarkers play a central role in the diagnosis of disease and assessment of its course. Among the markers now in use are genes, proteins, hormones, lipids and other classes of molecules. Biomarkers can be found in the blood, in cerebrospinal fluid, urine and various types of tissues, but most of ...