44 Current news of LMU

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Gene editing: Taming CRISPR’s collateral damage

Simple method to detect unintended alterations in the target gene itself – results indicate that such on-target events occur at high frequency

28-May-2020

CRISPR-Cas9 can alter genes at pre-defined sites in specific ways, but it does not always act as planned. An LMU team has now developed a simple method to detect unintended ‘on-target’ events, and shown that they often occur in human stem cells. The gene-editing system CRISPR-Cas9 has ...

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Lifting the lid on beta-barrels

02-Apr-2020

The interaction between biotin and streptavidin is a well-established experimental tool in bionanotechnology. LMU physicists have now shown that the mechanical stability of the complex is dependent on the precise geometry of the interface. Mechanical forces play a vital role at all levels in ...

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Tonsils as a testbed

02-Mar-2020

Biomedical researchers at LMU have isolated immune cells from human tonsils obtained following routine surgery, and used them to analyze aspects of the immune response and test the effects of anti-inflammatory agents at the cellular level. Human tissues that have been surgically removed from ...

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Gene scissors against incurable muscular disease

New gene correction therapy

30-Jan-2020

Duchenne type muscular dystrophy (DMD) is the most common hereditary muscular disease among children. A Munich based team has developed a gene therapy that may provide permanent relief for those suffering from DMD. LMU researcher Eckhard Wolf was involved in the study. Muscles need dystrophin in ...

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All in a flash! Eliminate proteins from cells with a flash of light

24-Jan-2020

LMU scientists have developed a tool to eliminate essential proteins from cells with a flash of light. The new method makes it possible to study the function of essential proteins. Proteins not only provide much of the structural architecture of cells, they also perform most of the executive ...

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A fine sense for molecules

Unique laser technology for the analysis of the molecular composition of biological samples

07-Jan-2020

At the biochemical level, organisms can be thought of as complex collections of different species of molecules. In the course of their metabolism, biological cells synthesize chemical compounds, and modify them in multifarious ways. Many of these products are released into the intercellular ...

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AI-driven single blood cell classification

New method to support physicians in leukemia diagnostics

14-Nov-2019

For the first time, researchers from Helmholtz Zentrum München and the University Hospital of LMU Munich show that deep learning algorithms perform similar to human experts when classifying blood samples from patients suffering from acute myeloid leukemia (AML). Their proof of concept study paves ...

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An ultrafast glimpse of the photochemistry of the atmosphere

15-Oct-2019

Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have explored the initial consequences of the interaction of light with molecules on the surface of nanoscopic aerosols. The nanocosmos is constantly in motion. All natural processes are ultimately determined by the interplay between ...

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Bringing cancer medication safely to its destination

12-Aug-2019

Treating cancer more selectively and more effectively – this could be achieved with an innovative technology developed by teams of researchers at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and the Ludwig-Maximilians-Universität München (LMU). The process transforms proteins ...

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Tiny “blinkers” reveal molecules inside cells

18-Mar-2019

LMU physicists led by Ralf Jungmann introduce an entirely new approach to super-resolution microscopy: Tiny ‘blinkers’ enable simultaneous imaging of multiple biomolecules. In everyday life, blinking lights can send signals – for example, that a car is going to turn. Now, researchers have ...

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