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A massive advance in spectrometry

Study results may lead to more accurate medical, biological, and chemical tests

21-Jan-2021

Mass spectrometers (MS) have become essential tools in chemistry and biology laboratories. The ability to quickly identify the chemical components in a sample allows them to take part in a diverse array of experiments, including radiocarbon dating, protein analysis, and monitoring drug ...

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Complete filling of batches of nanopipettes

10-Jan-2020

Nanopipettes, in which a nanoscale channel is filled with a solution, are used in all kinds of nanotechnology applications, including scanning-probe microscopy. Bringing a solution into a nanopipette with a pore diameter below 10 nanometer is challenging, however, since capillary forces prevent ...

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Virulence factor of the influenza A virus mapped in real-time

22-May-2019

The influenza A viruses, which have instigated deadly pandemics in the past, still remain a major global public health problem until today. Molecules known as virulence factors are produced by bacteria, viruses, and fungi to help them to infect host cells. One of virulence factors found in the ...

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Lipids and proteins: Further evidence for functional crosstalk in cells

19-Jun-2018

Researchers at Kanazawa University have uncovered the role of lipids in facilitating a functional switch between two forms of a cellular enzyme: Peroxiredoxin (Prxs). Their study published in the Journal of Molecular Biology explains how negatively charged membrane lipids can bind to Prxs, and ...

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Elucidation of vibration energy of a single molecule in an external force field

14-May-2018

A molecule adsorbed on a surface (Figure 1A) vibrates on the surface (Figure 1B). The vibration energy is determined by the mass of the molecule and by the restoring forces exerted on the molecule. The restoring force originates from the interaction within the molecule and with the surface. By ...

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High-speed FM-AFM and simulation reveal atomistic dissolution processes of calcite in water

28-Jul-2017

Calcite is one of the most abundant components of the Earth crust, the outer-most layer of the Earth, constituting as the largest carbon reservoir in the global carbon cycle in nature. Thus, large-scale dissolution of calcite would give an enormous impact on the weather, geography, aquatic ...

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Colon cancer nuclear pore dynamics are captured by HS-AFM

04-Jul-2017

One of the key reasons for cancer mortality is caused by the highly invasive behaviour of cancer cells, which is often due to aggressive metastasis. Metastasis is facilitated by various growth factors and cytokines secreted from cells of the immune system, which operate through various signaling ...

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The guide to biomolecular movie-making

08-Jan-2013

High-speed atomic force microscopy (HS-AFM) is providing the means to produce dramatic footage of moving biomolecules, and scientists at Kanazawa University leading the field. Toshio Ando and co-workers at Kanazawa University have developed and used HS-AFM to increase our understanding of several ...

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