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“Honey, I shrunk the detector”

Researchers have developed the world’s smallest ultrasound detector

18-Sep-2020

Researchers at Helmholtz Zentrum München and the Technical University of Munich (TUM) have developed the world’s smallest ultrasound detector. It is based on miniaturized photonic circuits on top of a silicon chip. With a size 100 times smaller than an average human hair, the new detector can ...

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Beta cells from stem cells: Potential for cell replacement therapy

Quality control with CD177 can help save lots of time, efforts and money

29-Apr-2020

The loss of insulin-secreting beta cells by autoimmune destruction leads to type 1 diabetes. Clinical islet cell transplantation has the potential to cure diabetes, but donor pancreases are rare. In a new study, a group of researchers developed an improved pluripotent stem cell differentiation ...

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Looking at the good vibes of molecules: a new method for label-free metabolic imaging

09-Jan-2020

Label-free dynamic detection of biomolecules is a major challenge in live-cell microscopy. The simultaneous visualization of dynamic alterations for classes of metabolites, such as carbohydrates and lipids, was an unmet need in biomedical research. Now, a novel imaging method developed by a ...

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AI-driven single blood cell classification

New method to support physicians in leukemia diagnostics

14-Nov-2019

For the first time, researchers from Helmholtz Zentrum München and the University Hospital of LMU Munich show that deep learning algorithms perform similar to human experts when classifying blood samples from patients suffering from acute myeloid leukemia (AML). Their proof of concept study paves ...

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Cell atlas of the aging lung

01-Mar-2019

Aging promotes lung function decline and increases susceptibility to diseases of the respiratory tract. In order to understand these effects in detail, researchers at Helmholtz Zentrum München, a partner in the German Center for Lung Research (DZL), analyzed the aging process in the lung at ...

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Using artificial intelligence for error correction in single cell analyses

28-Jan-2019

Modern technology makes it possible to sequence individual cells and to identify which genes are currently being expressed in each cell. These methods are sensitive and consequently error prone. Devices, environment and biology itself can be responsible for failures and differences between ...

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New insight into the maturation of miRNAs

04-Jul-2018

An international research team led by Helmholtz Zentrum München, Technical University of Munich and the University of Edinburgh has used an integrated structural biological approach to elucidate the maturation of a cancer-causing microRNA in gene regulation. In the future, the authors hope to ...

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New software processes huge amounts of single-cell data

Comprehensive analysis of large gene-expression datasets

13-Feb-2018

Scientists from the Helmholtz Zentrum München have developed a program that is able to help manage enormous datasets. The software, named Scanpy, is a candidate for analyzing the Human Cell Atlas. “It’s about analyzing gene-expression data of a large number of individual cells,” explains lead ...

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Repetitive elements shape embryonic chromatin landscape

30-Aug-2017

Retrotransposons are repetitive elements that form almost half of the mammalian genome. Even though they are so common, they have previously been considered to be fairly insignificant. Together with colleagues from the USA, scientists from the Helmholtz Zentrum München have now shown that ...

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Detour diagnosis

Rare genetic disorders: new approach uses RNA in search for genetic triggers

14-Jun-2017

In about half of all patients with rare hereditary disorders, it is still unclear what exact position of the genome is responsible for their condition. One reason for this is the enormous quantity of information encoded in human genes. Scientists from the fields of informatics and medicine have ...

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