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Delivering on the Promise of the Paperless Lab

11-09-2012

Organizations have made significant investments in enterprise and laboratory tools, technologies and solutions to help improve productivity, better manage data/information and optimize their business processes. However, the reality is that most companies have not reaped the return on investment (ROI) or efficiency gains that they planned. This article demonstrates how the Paperless Lab can...

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Microwave freeze drying of fruits & vegetables

08-08-2012

The concept of microwave freeze drying is based on smaller footprint, higher energy efficiency and better quality in terms of volatiles compared to conventional freeze drying with long vacuum vessels and huge product loads.The application of microwave freeze drying in industrial drying systems is of increasing interest, particularly because of the increasing energy and operational efficiencies...

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From Glass Thermometer to Highly Dynamic Temperature Control Technology

A Juchheim family’s history of success and innovation since 1926

23-07-2012

The first glass thermometers were relatively primitive devices. Equipped with fixed contacts, they were capable of only limited interaction with a relay for things like switching an electric heater on or off or triggering an acoustic warning function. More sophisticated applications required a new development in technology in order to enable variable adjustment of the desired temperature......

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Asymmetric Flow Field Flow Fractionation (AF4) - A Powerful Method for Polymer Characterization

05-11-2009

The AF4-MALS combined technique can serve as a routine method for polymer analysis and characterization. AF4 provides separation efficiency entirely comparable with traditionally used and so far dominating SEC. In addition, it yields superior separation of branched polymers, polymers containing ultra high molar mass fractions up to at least 108 g/mol, and nanoparticles. This contribution outlines the theoretical background of the method and shows several examples of its use, e.g. separation of high molecular weight polymers and particles. While SEC will certainly continue to be the most frequently employed method of polymer analysis, for many samples the description of molecular structure is more detailed if both SEC and AF4 are used. The possibility to run both SEC and AF4 on the same experimental set-up makes the AF4 method a powerful and versatile tool for the characterization of a variety of synthetic and natural polymers and related materials....

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Burn injuries under freezing (labor protection) conditions?

Optimal protection when handling cryogenic liquefied gases

28-10-2009

"A little splash of liquid nitrogen hasn't hurt anybody" - this happens to be a widespread opinion in many laboratories. The real dangers connected to cryogenic gases many people had to learn firsthand, unexpected and painful. Skin irritation, cell and tissue damage or severe burn injuries may occur, depending on the type of contact and exposure time. There are less possibilities of medical treatment than for injuries caused by influence of heat...

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Polyether-Modified Silicones for Cosmetic Applications

20-07-2009

Polyether-modified silicones have a long history of use in the personal care industry as emulsifiers and dispersants, as well as stabilizers for water-in-oil systems. However, because of their external phase type, water-in-oil systems tend to display poor aesthetics, such as greasiness, tackiness and slow absorption. A new polyether-modified silicone, PEG/PPG-19/19 dimethicone (and) C13-16 isoparaffin (and) C10-13 isoparaffin, was evaluated for its potential to aid in the production of stable water-in-silicone and water-in-oil formulations with unique textures and enhanced aesthetics. Various oil phases were studied, including silicone oils, organic oils, and a combination of both. Results of the evaluations demonstrate the versatility of the new material, and prototype formulations illustrate its broad utility...

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Homogeneous IgG AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus

Z' value of 0.92 indicates a highly robust assay combined with high quality instrumentation

27-04-2009

Immunoglobulins or antibodies are proteins that are involved in the immune response. That makes them interesting drug targets. This application note shows the detection of the immunoglobulin IgG using an AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus. The AlphaLISA® technology utilizes oxygen to start a cascade of chemical reactions resulting in a luminescence signal at 615 nm. Sensitivity and Z´values obtained in different plate formats are presented....

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Predictor(TM) hERG Fluorescence Polarization Assay Kit performed on the PHERAstar/PHERAstar Plus

28-08-2008

The potential for cardiotoxic side-effects continues to challenge the development of small molecule based therapies. These intolerable side-effects are often precipitated by drug-induced long QT syndrome (LQT), which is often linked to blocking the human ether-a-go-go related gene (hERG) potassium channel. Although patch-clamp electrophysiology remains the gold standard for determining the interaction of compounds with the function of the hERG channel, radioligand displacement assays have proven to be a cost-effective initial alternative assay for hERG channel liability at early stages of compound development....

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Detection of NADH and NADPH with the Omega's High Speed, Full UV/Vis Absorbance Spectrometer

25-08-2008

Nicotinamide Adenine Dinucleotide (NAD+), reduced nicotinamide adenine dinucleotide (NADH), nicotinamide adenine dinucleotide phosphate (NADP+) and reduced nicotinamide adenine dinucleotide phosphate (NADPH) have been known to play vital roles in energy metabolism, antioxidation, and reductive biosynthesis. In recent years, these co-factors have been shown to be involved in other physiological functions as well, including aging, oxidative stress, intracellular calcium homeostasis, ROS production, cell death and gene expression....

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"Green Chemstry" in the Laboratory

Using mills as efficient and ecologically friendly synthesis reactors

25-06-2008

The term "green chemistry" is commonly used to describe chemical procedures which meet specific requirements with regards to the conservation of resources and protection of the environment. The objective is to avoid undesired by-products by selecting adequate reaction procedures and media. A typical example is the production of bio fuel which has become an ecologically friendly alternative for many drivers....

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