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Delivering on the Promise of the Paperless Lab

11-09-2012

Organizations have made significant investments in enterprise and laboratory tools, technologies and solutions to help improve productivity, better manage data/information and optimize their business processes. However, the reality is that most companies have not reaped the return on investment (ROI) or efficiency gains that they planned. This article demonstrates how the Paperless Lab can...

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Microwave freeze drying of fruits & vegetables

08-08-2012

The concept of microwave freeze drying is based on smaller footprint, higher energy efficiency and better quality in terms of volatiles compared to conventional freeze drying with long vacuum vessels and huge product loads.The application of microwave freeze drying in industrial drying systems is of increasing interest, particularly because of the increasing energy and operational efficiencies...

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From Glass Thermometer to Highly Dynamic Temperature Control Technology

A Juchheim family’s history of success and innovation since 1926

23-07-2012

The first glass thermometers were relatively primitive devices. Equipped with fixed contacts, they were capable of only limited interaction with a relay for things like switching an electric heater on or off or triggering an acoustic warning function. More sophisticated applications required a new development in technology in order to enable variable adjustment of the desired temperature......

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Field-Flow Fractionation - The Universal Separation Principle for Particle and Macromolecule Characterization

22-09-2010

High molecular weight polymers, bio molecules or particles in a range of a few nanometers up to several microns are more and more important in science and technology. Many applications are based on the specific properties of these materials. For this reason, an exact knowledge of the molar mass or particle sizes distribution is essential for later application as well as for optimization of the production processes or quality control. In addition the knowledge about the chain structure of macromolecules or biopolymers as well as about the shape of particles is often necessary. For this reason those samples, which often can be very complex systems, have to be separated according to parameters such as e.g. hydrodynamic volume or molecular weight. After the separation process the resulting narrow dispersed fractions are detected with different techniques....

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New Silicone Technologies for Skin Care

16-11-2009

In today's competitive skin care market, consumers look for a range of benefits, superior aesthetics and cost effectiveness. In response, formulators strive to create products that are multifunctional, easy to use and effective in small quantities. At the same time, the most successful products deliver benefits that stand out from those of the competition. Creams, lotions and color cosmetics must be easy to spread and comfortable to wear, without feeling tacky or greasy. Silicones have been popular ingredients in skin care products for more than fifty years. These versatile materials are known for their emolliency, wetting and spreading characteristics and ability to provide unique aesthetics. As technology continues to evolve, silicones increasingly offer multifunctional, high performance properties. This article reviews some of the newest silicone technologies available for the formulation of innovative skin care products...

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Automated Dynamic Light Scattering

09-11-2009

DLS analysis is a widely applied, non-invasive method for measuring the effective size of molecules in solution. This technique yields valuable information for the characterization of molecules and particles. It facilitates formerly laborious and time consuming measurements, e.g. screening for aggregates or determining optimal crystallization conditions for proteins. The Wyatt Plate Reader is the instrument of choice for any application where molecular size, stability and aggregation are of interest. It reads industry standard microplates with up to 1536 samples automatically and temperature-controlled, if desired. The applications of the technique are wide ranging and include many of the fastest growing areas of research - proteins, biomaterials, liposomes and micelles as well as the established uses for particle sizing and aggregation detection. Conscious of the numerous characterization challenges in the area of drug delivery systems and therapeutic antibodies...

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Asymmetric Flow Field Flow Fractionation (AF4) - A Powerful Method for Polymer Characterization

05-11-2009

The AF4-MALS combined technique can serve as a routine method for polymer analysis and characterization. AF4 provides separation efficiency entirely comparable with traditionally used and so far dominating SEC. In addition, it yields superior separation of branched polymers, polymers containing ultra high molar mass fractions up to at least 108 g/mol, and nanoparticles. This contribution outlines the theoretical background of the method and shows several examples of its use, e.g. separation of high molecular weight polymers and particles. While SEC will certainly continue to be the most frequently employed method of polymer analysis, for many samples the description of molecular structure is more detailed if both SEC and AF4 are used. The possibility to run both SEC and AF4 on the same experimental set-up makes the AF4 method a powerful and versatile tool for the characterization of a variety of synthetic and natural polymers and related materials....

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Burn injuries under freezing (labor protection) conditions?

Optimal protection when handling cryogenic liquefied gases

28-10-2009

"A little splash of liquid nitrogen hasn't hurt anybody" - this happens to be a widespread opinion in many laboratories. The real dangers connected to cryogenic gases many people had to learn firsthand, unexpected and painful. Skin irritation, cell and tissue damage or severe burn injuries may occur, depending on the type of contact and exposure time. There are less possibilities of medical treatment than for injuries caused by influence of heat...

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Polyether-Modified Silicones for Cosmetic Applications

20-07-2009

Polyether-modified silicones have a long history of use in the personal care industry as emulsifiers and dispersants, as well as stabilizers for water-in-oil systems. However, because of their external phase type, water-in-oil systems tend to display poor aesthetics, such as greasiness, tackiness and slow absorption. A new polyether-modified silicone, PEG/PPG-19/19 dimethicone (and) C13-16 isoparaffin (and) C10-13 isoparaffin, was evaluated for its potential to aid in the production of stable water-in-silicone and water-in-oil formulations with unique textures and enhanced aesthetics. Various oil phases were studied, including silicone oils, organic oils, and a combination of both. Results of the evaluations demonstrate the versatility of the new material, and prototype formulations illustrate its broad utility...

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Homogeneous IgG AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus

Z' value of 0.92 indicates a highly robust assay combined with high quality instrumentation

27-04-2009

Immunoglobulins or antibodies are proteins that are involved in the immune response. That makes them interesting drug targets. This application note shows the detection of the immunoglobulin IgG using an AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus. The AlphaLISA® technology utilizes oxygen to start a cascade of chemical reactions resulting in a luminescence signal at 615 nm. Sensitivity and Z´values obtained in different plate formats are presented....

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