UPLC^® Technology for Performance without Compromises

UPLC^® Technology, which has been adopted successfully in laboratories around the world for the most demanding separations, is a highly robust, dependable, and reproducible system. What differentiates the system’s holistic design is Waters’ patented sub-2 µm hybrid particle chemistry, significant benefits over today's HPLC systems equipped with standard 5 µm particle chemistries.

The ACQUITY UPLC System, used on its own or paired with Waters optical and MS detection technologies, provides unique end-to-end solutions for all industries
ACQUITY Ultra Performance LC^®System Advantages:

 Efficiency gains with sub-2 µm particles:

• Provides 3X higher efficiency than 5 µm particles
• 70% higher resolution than 5 µm particles
• For gradient separations, peak capacity is used to measure the resolving power
  

Better information gained when analyzing more samples per unit time:

• Column length can be reduced by a factor of three with methods transitioned from 5 µm particles to sub-2 µm particles, with the same efficiency
• Separations can be run at a 3X higher flow rate
• Generate a 9X increase in throughput with no loss in resolution
  

Detect compounds at increasingly lower levels without inherent changes to the detection mode, either optical or MS:

• The ACQUITY UPLC^® System with sub-2 µm particles provides up to 70% higher sensitivity
• In the case of equal efficiency but faster analysis times, the equivalent is 3X higher sensitivity than 5 µm particles
• Beyond optical detection and looking at MS, the less dispersed peaks with higher concentration effectively yield improved ionization efficiency, making ACQUITY UPLC the ideal inlet for any MS detector