The Mass Spec for most demanding quantitative applications

The Waters Xevo TQ-S tandem mass spectrometer represents a step change in targeted quantitative UPLC/Multiple Reaction Monitoring (MRM) analysis. This system is capable of accurately measuring target compounds in complex samples at femtogram levels or below.

The Xevo TQ-S is designed for UPLC®/MS/MS applications such as biological and medical research, bioanalysis, food safety, environmental monitoring and forensics testing where speed, sensitivity, and accuracy are of paramount importance.

The Xevo TQ-S features new StepWave™ ion-transfer technology, a revolutionary off-axis design for dramatically increasing the efficiency of ion transfer from the ion source to the quadrupole MS analyzer while at the same time actively eliminating undesirable neutral contaminants. This gives the Xevo TQ-S impressive class-leading sensitivity. When compared to earlier generation mass spectrometer models the chromatographic peak areas are typically more than 30 times bigger and the signal-to-noise ratios are typically 5 to 10 times better.

The novel, high speed transfer optics and collision cell design allows the TQ-S system to acquire both full scan MS and MRM data simultaneously on narrow, 1-2 second wide UPLC peaks and still obtain >12 points across the peak, something that is particularly useful in methods development when dealing with a complex matrix, for monitoring for the presence of new components in the sample during routine analysis or troubleshooting an assay.

With the Xevo TQ-S mass spectrometer, scientists can now confidently quantify compounds at lower concentrations than previously possible. The instrument’s sensitivity also allows scientists to consider diluting samples in order to reduce matrix effects that interfere with compound measurements. They can also work with smaller sample volumes, a big benefit when analyzing precious biological samples taken from animals or humans.

StepWave™: The patented StepWave consists of two ion transfer stages, both of which are T-Wave*™-enabled. The first stage is revolutionary in its design, constructed from two stacked ring electrode devices that are conjoined to give a single off-axis ion transfer lens with unique properties. As the ion beam passes through the source sampling orifice it undergoes a certain amount of expansion.

The entrance of the StepWave is designed to be large enough to efficiently capture all of the ions in this expanded ion cloud. The design of the first stage ensures that all the ions are efficiently focused and directed up into the second stage. The unique off-axis design ensures that any neutral materials entering the source sampling orifice are actively extracted from the system.

ScanWave™: With its unique collision cell, Xevo TQ -S enables you to better address your analytical needs with the option to operate in a new ScanWave enhanced product ion scanning mode. In this mode, ions are accumulated and then separated according to their mass-to-charge ratio (m/z). Synchronizing the release of these ions with the scanning of the second quadrupole mass analyzer significantly enhances the signal intensity of full scan product ion spectra. Simply put, this enables you to more easily confirm the identities and structures of your analytes of interest.

RADAR™: an information-rich acquisition approach that allows you to collect highly specific quantitative data for target compounds while providing the ability to visualize all other components in sample matrices

Ion Source Options: The universal ion source architecture of Xevo TQ-S allows the widest range of ionization techniques to be utilized as well as the very latest innovations in ionization technologies. So you'll have limitless choice in experimental options.  When you need options and time is critical, the ion sources are quickly interchangeable and ready to use within minutes.

• ESI – Electrospray Ionization
• APCI – Atmospheric Pressure Chemical Ionization
• ESCi^® – Dual ESI und APCI
• APPI – Atmospharic Pressure Photo Ionization
• ASAP – Atmospheric Solids Analysis Probe
• APGC – Atmospheric Pressure Gas Chromatography
• TRIZIAC UPLC^® – Plug and Play nanoFlow
• nanoFlow™ ESI