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  • A path toward more powerful tabletop accelerators

    Making a tabletop particle accelerator just got easier. A new study shows that certain requirements for the lasers used in an emerging type of small-area particle accelerator can be significantly relaxed. Researchers hope the finding could bring about a new era of accelerators that would need just a more

  • From surgery to laboratory and back again

    A University of York scientist's experience in seeing his partner in hospital recovering from a double lung transplant prompted him to design and synthesise new chemical agents that could revolutionise post-operative patient care. Professor Dave Smith, of the University's Department of Chemistry, le more

  • Innovative technology for the enrichment of free-circulating DNA

    After a two year period of development Analytik Jena has launched an innovative technology to enrich and isolate free-circulating DNA. Free-circulating DNA occurs in plasma, serum, and urine, among other things, but only in small fragments and very low concentrations. In order to isolate them, large more

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  • Homogeneous IgG AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus

    Immunoglobulins or antibodies are proteins that are involved in the immune response. That makes them interesting drug targets. This application note shows the detection of the immunoglobulin IgG using an AlphaLISA® assay performed on BMG LABTECH's PHERAstar Plus. The AlphaLISA® technology utilizes oxygen to start a cascade of chemical reactions resulting in a luminescence signal at 615 nm. Sensitivity and Z´values obtained in different plate formats are presented. more

  • High sensitive detection of follistatin by Imperacer®: an initial study on the way to analytical gene-doping tests

    For the understanding of interactions in the muscle-growth directing myostatin-pathway and therefore also for the establishment of high sensitive detection strategies for gene-doping, detailed studies of protein concentration levels in biological matrices and appropriate highly sensitive analytic techniques for quantitative monitoring of these biomarkers are required. In this work, the development of a high sensitive assay for follistatin based on the Imperacer® technology is described. The quantification limit in human serum was found at 60 pg/ml in only 6 µl sample volume. With this initial assay we demonstrate the first application in a set of analytical tests for a high sensitive myostatin pathway related profiling. more

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