13 Current news of Vanderbilt University

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Evolution of a deadly virus

Genomic sequences reveal that Florida is a major source of a mosquito-borne virus

25-May-2018

Infections caused by the mosquito-borne eastern equine encephalitis virus (EEEV) are severe and have high mortality rates for horses - 90 percent - and humans - 33 percent, with significant brain damage in most human survivors. Florida has been hypothesized to be the source of EEEV epidemics, but ...

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New view of the heartbeat

10-Apr-2018

The human cardiac voltage-gated sodium channel (Nav1.5) plays a critical role in maintaining regular heartbeats. Mutations in Nav1.5 cause life-threatening heart rhythm disorders (arrhythmias). Nav1.5 is sensitive to the calcium-ion sensor protein calmodulin (CaM); however, the exact mechanism of ...

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Tracking protein’s role in stem cell function

26-Mar-2018

MCL-1 is a member of the BCL-2 family of proteins important for blocking apoptosis, or programmed cell death. Many types of cancer cells escape the body’s effort to kill them by overexpressing MCL-1. However, new evidence from Vanderbilt University researchers indicates that MCL-1 also helps ...

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Alzheimer’s study establishes way to measure resilience

14-Nov-2016

Vanderbilt researchers have established a new measure of resilience to cognitive impairment in people with asymptomatic Alzheimer’s disease. They essentially flipped the standard approach used by researchers when mining the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database, said Timothy ...

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Bioluminescent sensor causes brain cells to glow in the dark

31-Oct-2016

The probe, which was developed by a team of Vanderbilt scientists, is a genetically modified form of luciferase, the enzyme that a number of other species including fireflies use to produce light. The scientists created the technique as a new and improved method for tracking the interactions ...

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Single-cell study of tumor samples

28-Oct-2016

The presence of various cell types in tumors – cellular heterogeneity – makes treatment challenging, since a therapy may kill one cell type but not affect another. Studying heterogeneous cell populations requires single-cell analysis. Ken Lau , Ph.D., and colleagues previously described a method ...

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DNA damage response protein

25-Oct-2016

Researchers at Vanderbilt University and Vanderbilt University Medical Center have determined that a previously uncharacterized protein called ETAA1 is a “replication stress response protein” with an essential role in maintaining the integrity of the genome. The finding by David Cortez , Ph.D., ...

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Breast cancer: finding the smoking gun

A new method developed at Vanderbilt may help “inventory” all tumor-promoting genes.

22-Jul-2016

Many genes are associated with cancer. The trick is proving they actually promote tumor formation. One approach, detailed by Ian Macara , Ph.D., and colleagues is an in vivo “gain-of-function” screen. The researchers used a gene “library” (complementary DNA carried by lentivirus) to increase the ...

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Pulmonary fibrosis culprits

Isoketal-modified proteins as a potential therapeutic target of pulmonary fibrosis

08-Jun-2016

Isoketals (IsoKs) – highly reactive compounds formed when membrane lipids are attacked by free radicals – are emerging as a mechanistic link between pathogenic reactive oxygen species and disease progression. However, the identity of IsoK-modified proteins and whether isoketal generation is ...

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How to create nanowires only 3 atoms wide with an electron beam

30-Apr-2014

Junhao Lin, a Vanderbilt University Ph.D. student and visiting scientist at Oak Ridge National Laboratory (ORNL), has found a way to use a finely focused beam of electrons to create some of the smallest wires ever made. The flexible metallic wires are only three atoms wide: One thousandth the ...

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