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Potent, puzzling and (now less) toxic: How antifungal drug works

17-04-2014

Scientists have solved a decades-old medical mystery – and in the process have found a potentially less toxic way to fight invasive fungal infections, which kill about 1.5 million people a year. The researchers say they now understand the mechanism of action of amphotericin, an antifungal drug ...

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Nano shake-up

UD researchers demonstrate that processing can affect size of nanocarriers for targeted drug delivery

16-04-2014

Significant advances have been made in chemotherapy over the past decade, but targeting drugs to cancer cells while avoiding healthy tissues continues to be a major challenge. Nanotechnology has unlocked new pathways for targeted drug delivery, including the use of nanocarriers, or capsules, that ...

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New technique to sharpen microscope images

15-04-2014

The complexity of biology can befuddle even the most sophisticated light microscopes. Biological samples bend light in unpredictable ways, returning difficult-to-interpret information to the microscope and distorting the resulting image. New imaging technology developed at the Howard Hughes ...

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No compromises: Short, flexible, reusable AFM probe

11-04-2014

JILA researchers have engineered a short, flexible, reusable probe for the atomic force microscope (AFM) that enables state-of-the-art precision and stability in picoscale force measurements. Shorter, softer and more agile than standard and recently enhanced AFM probes, the JILA tips will benefit ...

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Toward a faster way to diagnose stroke

11-04-2014

When someone suffers from a stroke, a silent countdown begins. A fast diagnosis and treatment can mean the difference between life and death. So scientists are working on a new blood test that one day could rapidly confirm whether someone is having a stroke and what kind. Their report appears in ...

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Amino acid fingerprints revealed in new study

08-04-2014

Some three billion base pairs make up the human genome—the floor plan of life. In 2003, the Human Genome Project announced the successful decryption of this code, a tour de force that continues to supply a stream of insights relevant to human health and disease. Nevertheless, the primary actors ...

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Going global

Stowers team reports genome-wide analysis of genes that drive cell division in a multicellular organism

04-04-2014

In textbooks, the grand-finale of cell division is the tug-of-war fought inside dividing cells as duplicated pairs of chromosomes get dragged in opposite directions into daughter cells. This process, called mitosis, is visually stunning to observe under a microscope. Equally stunning to cell ...

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Simple microfluidic devices now have valves

04-04-2014

Researchers at the National Institute of Standards and Technology (NIST) have added yet another innovation—miniature valves—to their ever-growing collection of inexpensive, easy-to-manufacture and highly efficient microfluidic devices made from plastic films and double-sided tape. Traditionally, ...

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Good vibrations: Using light-heated water to deliver drugs

03-04-2014

Researchers from the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, in collaboration with materials scientists, engineers and neurobiologists, have discovered a new mechanism for using light to activate drug-delivering nanoparticles and other targeted ...

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Erasing a genetic mutation

01-04-2014

Using a new gene-editing system based on bacterial proteins, MIT researchers have cured mice of a rare liver disorder caused by a single genetic mutation. The findings, described in Nature Biotechnology, offer the first evidence that this gene-editing technique, known as CRISPR, can reverse ...

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